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Sphingolipids have been suggested to act as second messengers for an array of cellular signaling activities in plant cells, including stress responses and programmed cell death (PCD). However, the mechanisms underpinning these processes are not well understood. Here, we report that an Arabidopsis mutant, fumonisin B1 resistant11-1 (fbr11-1), which fails to(More)
BACKGROUND Gene expression studies of peripheral blood mononuclear cells from patients with systemic lupus erythematosus (SLE) have demonstrated a type I interferon signature and increased expression of inflammatory cytokine genes. Studies of patients with Aicardi Goutières syndrome, commonly cited as a single gene model for SLE, have suggested that(More)
In this paper, the lightning-generated electromagnetic fields over lossy ground produced by lightning strikes either to flat ground or to a tall tower are calculated using the 2-D finite-difference time-domain (FDTD) method. The resultant horizontal and vertical electric fields are used as forcing functions in the discretized Agrawal electromagnetic(More)
Sphingolipids are important signaling molecules involved in various cellular activities. De novo sphingolipid synthesis is initiated by a rate-limiting enzyme, serine palmitoyltransferase (SPT), a heterodimer consisting of LONG-CHAIN BASE1 (LCB1) and LCB2 subunits. A mutation in the Arabidopsis thaliana LCB1 gene, lcb1-1, was found to cause embryo(More)
Noncoding RNAs have been implicated in the regulation of expression of numerous genes; however, the mechanism is not fully understood. We identified bidirectional, long noncoding RNAs upstream of the TNF gene using five different methods. They arose in a region where the repressors LRRFIP1, EZH2, and SUZ12 were demonstrated to bind, suggesting a role in(More)
The aberrant expression of microRNAs (miRNAs) has been found in various types of cancer. The present study found miR-20a was significantly up-regulated in prostate cancer compared with normal prostate tissues. Patients with a higher miR-20a expression had a Gleason score of 7-10 and shorter survival time. The transwell and wound healing assays revealed that(More)
BACKGROUND Complement-C1q TNF-related protein 1 (CTRP1), a member of the CTRP superfamily, possesses anti-inflammatory and anti-diabetic effects in mice. However, the clinical relevance of CTRP1 has been seldom explored. The current study aimed to investigate the association of circulating CTRP1 and type 2 diabetes mellitus (T2DM) in a Chinese population.(More)
A novel high-efficient two-step finite-difference time-domain (FDTD) method is proposed to analyze the lightning-induced voltages on transmission lines (TLs) in this paper. The proposed method includes two steps. The first step is to calculate, using the 2-D FDTD method, electromagnetic fields that are radiated from a vertical lightning channel and(More)
This paper presents a novel 3-D leapfrog hybrid implicit-explicit finite-difference time-domain (HIE-FDTD) method. By first adopting the Peaceman-Rachford scheme and then the one-step leapfrog scheme, the proposed HIE-FDTD algorithm is implemented in the same manner as the traditional finite-difference time-domain method in which the implicit scheme was(More)
OBJECTIVE To investigate the expression and correlation of transforming growth factor-β1 (TGF-β1) and fibroblast growth factor receptor 4 (FGFR4) in human hepatocellular carcinoma (HCC) and the relationship with clinicopathological features and prognosis. MATERIALS AND METHODS The expression of TGF-β1 and FGFR4 in 126 HCC samples was detected(More)