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Ku70 is one component of a protein complex, the Ku70/Ku80 heterodimer, which binds to DNA double-strand breaks and activates DNA-dependent protein kinase (DNA-PK), leading to DNA damage repair. Our previous work has confirmed that Ku70 is important for DNA damage repair in that Ku70 deficiency compromises the ability of cells to repair DNA double-strand(More)
Forsythia suspensa (Thunb.) Vahl leaves have been consumed in China as a health-promoting functional tea for centuries. Three new polyhydroxytriterpenoid glycosides named suspensanosides A-C (1-3), seven known polyhydroxytriterpenoids (4-10), and 12 known phenolics (11-22) were identified from F. suspensa leaves. Compounds 1-10, 15-17, and 22 have not been(More)
We report here our studies on the ¡nhibitionaleffect of 45°Cheat shock on transcriptions! and translational activity and their subsequent recovery at 37°Cin Rat-1 cells, thermotolerant Rat-1 cells ('IT Rat-1), and Rat-1 cells transfected with human hsp70 gene (IIR24, M21). Specifically, we ask whether overexpression of hspTOprotects cells from(More)
Isoalantolactone (IAL) is an active sesquiterpene naturally present in many vegetables, condiments and medicinal plants. In this study, an efficient strategy was developed for the identification of metabolites following the in vivo metabolism and in vitro biotransformation of IAL with rat intestinal bacteria utilizing ultra performance liquid chromatography(More)
A new taxane glycoside was isolated from a methanol extract of the needles of Taxus cuspidata. The structure was established as 2alpha,9alpha,10beta-triacetoxytaxa-4(20),11-dien-13-one-5alpha-O-beta-D-glucopyranoside (1) on the basis of 1D- and 2D NMR and high-resolution fast atom bombardment mass spectral analyses.
OBJECTIVE To compare the biomechanical stability of acetabular transverse fracture fixed with single column locking reconstruction plate, locking reconstruction plate combined with lag screw, and double columns lag screws. METHODS Acetabular transverse fractures were established in 20 adult fresh semi-pelvis specimens, and divided into 5 groups randomly(More)
Alantolactone (AL), an active sesquiterpene originating from Inula helenium, is a potential anticancer and anti-inflammatory agent. However so far, studies on AL metabolism have not been reported. In the present study, we have investigated for the first time the in vivo and in vitro metabolites of AL using ultra performance liquid chromatography combined(More)
We report here our studies on the ¡nhibitionaleffect of 45°Cheat shock on transcriptions! and translational activity and their subsequent recovery at 37°Cin Rat-1 cells, thermotolerant Rat-1 cells ('IT Rat-1), and Rat-1 cells transfected with human hsp70 gene (IIR24, M21). Specifically, we ask whether overexpression of hspTOprotects cells from(More)
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