Lieke E. J. M. Scheepers

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OBJECTIVE To investigate whether the intestinal microbiota composition in early infancy is associated with subsequent weight development in children. METHODS Analyses were conducted within the KOALA Birth Cohort Study (n = 2834). This cohort originates from two recruitments groups: pregnant women with a conventional lifestyle (no selection based on(More)
OBJECTIVE The enzyme xanthine oxidoreductase (XOR) generates uric acid in the terminal steps of the purine metabolism; meanwhile reactive oxygen species are formed. We hypothesized that uric acid production, as assessed indirectly from XOR variants, is associated with hypertension. METHODS Among 2769 participants (48.3% men; mean age 40.7 years) randomly(More)
OBJECTIVE Elevated serum uric acid concentration has been associated with high blood pressure (BP) and hypertension. A putative underlying mechanism is the accumulation of reactive oxygen species when uric acid is generated by an increased enzyme activity of xanthine oxidase (XO). The aims of the present study were to investigate the associations between(More)
OBJECTIVE Accumulation of reactive oxygen species by increased uric acid production has been suggested as a possible underlying mechanism for the association between uric acid and high blood pressure (BP). We, therefore, investigated the association between serum uric acid concentration and 24-h urinary uric acid excretion, as proxy for uric acid(More)
Contrary to what is assumed, traditional birth attendants (TBAs) do not appear to be a clearly defined category of women with specialized knowledge and experience of assistance at deliveries in the local cultural situation at village level in the Anis region of the central highlands in Yemen. In the actual design of training for TBAs in Yemen, this results(More)
The objective of the present study is to explore knowledge, illness perceptions and stated practice behaviour in relation to gout in primary care. This is a mixed methods study among 32 general practitioners (GPs). The quantitative assessment included the Gout Knowledge Questionnaire (GKQ; range 0–10; better) and Brief Illness Perceptions Questionnaire(More)
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