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Spontaneous epileptiform activity in rat neocortex after controlled cortical impact injury.
A hallmark of severe traumatic brain injury (TBI) is the development of post-traumatic epilepsy (PTE). However, the mechanisms underlying PTE remain poorly understood. In this study, we used aExpand
Removal of superficial inhibition releases hyperexcitability in middle and deep horizontal slices from rat somatosensory neocortex
Synaptic physiology was studied in horizontal slices of rat somatosensory neocortex. Intrinsic properties of pyramidal neurons from horizontal slices resembled those recorded in cells from coronalExpand
Acute injury to superficial cortex leads to a decrease in synaptic inhibition and increase in excitation in neocortical layer V pyramidal cells.
Injury to the superficial layers of cerebral cortex produces alterations in the synaptic responses of local circuits that promote the development of seizures. To further delineate the specificExpand
Carbenoxolone modifies spontaneous inhibitory and excitatory synaptic transmission in rat somatosensory cortex
Gap junction (GJ) coupling between neocortical GABAergic interneurons plays a critical role in the synchronization of activity in cortical networks in physiological and pathophysiological states,Expand
Role of α4-containing GABAA receptors in limiting synaptic plasticity and spatial learning of female mice during the pubertal period
Expression of α4βδ GABAA receptors (GABARs) increases at the onset of puberty on dendritic spines of CA1 hippocampal pyramidal cells. These receptors reduce activation of NMDA receptors (NMDARs),Expand
Sevoflurane Blocks the Induction of Long-term Potentiation When Present during, but Not When Present Only before, the High-frequency Stimulation
Background: This study tests the hypothesis that sevoflurane blocks long-term potentiation only if it is present during the high-frequency stimulation that induces long-term potentiation. Methods:Expand
Pubertal Expression of α4βδ GABAA Receptors Reduces Seizure-Like Discharges in CA1 Hippocampus
More than half of children with epilepsy outgrow their seizures, yet the underlying mechanism is unknown. GABAergic inhibition increases at puberty in female mice due to expression of extrasynapticExpand
Early intervention with levetiracetam prevents the development of cortical hyperexcitability and spontaneous epileptiform activity in two models of neurotrauma in rats
This study examined the antiepileptogenic potential of the antiseizure drug (ASD) levetiracetam (LEV) using the in vitro traumatized-slice and in vivo controlled cortical impact (CCI) models ofExpand
Valproate Prevents Epileptiform Activity After Trauma in an In Vitro Model in Neocortical Slices
Purpose: Epileptogenesis is a hallmark of severe cortical trauma, with up to approximately 80% of patients experiencing seizures in the first 24 hours after penetrating head injury. An in vitro modelExpand
Decreased epileptic discharge of pubertal CA1 hippocampus is due to increased expression of α4βδ GABA-A receptors (P4.250)
OBJECTIVE: To test the role of extrasynaptic α4βδ GABA-A receptors (GABARs) in regulating ictal discharge of CA1 hippocampus in adolescent female mice. BACKGROUND: More than half of children withExpand