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Spontaneous epileptiform activity in rat neocortex after controlled cortical impact injury.
TLDR
Results indicate that during the first 2 weeks following severe CCI injury, there is a progressive development of neocortical hyperexcitability that ultimately leads to spontaneous epileptiform firing, suggesting a rapid epileptogenic process. Expand
Removal of superficial inhibition releases hyperexcitability in middle and deep horizontal slices from rat somatosensory neocortex
TLDR
Within cortex inhibition dominates superficially and excitation predominates in deeper layers, and enhancing fast inhibition can reset the excitation-inhibition balance, and prevent epileptogenesis. Expand
Lipopolysaccharide upregulates the expression of corticotropin-releasing hormone via MAP kinase pathway in rat peritoneal macrophages
TLDR
It is demonstrated that LPS significantly upregulates CRH expression through MAP kinase signaling pathway in rat peritoneal macrophages. Expand
Acute injury to superficial cortex leads to a decrease in synaptic inhibition and increase in excitation in neocortical layer V pyramidal cells.
TLDR
The findings suggest that acute injury to the superficial neocortical layers results in a disinhibition of cortical circuits that stems from a decline in GABA release likely due to the loss of superficial inhibitory interneurons and an enhancement of synaptic excitation consequent to an increase in the AMPA receptor unit conductance. Expand
Carbenoxolone modifies spontaneous inhibitory and excitatory synaptic transmission in rat somatosensory cortex
TLDR
In neocortex, blockade of GJs leads to an increase in spontaneous excitation by uncoupling GABAergic interneurons, and that electronic communication between inhibitory cells plays a significant role in regulating tonic synaptic excitation. Expand
Role of α4-containing GABAA receptors in limiting synaptic plasticity and spatial learning of female mice during the pubertal period
TLDR
It is suggested that knock-out of the GABAR α4 subunit restores synaptic plasticity and spatial learning at puberty and is consistent with the concept that the dendritic α4βδ GABAA receptors which emerge at puberty selectively impair CNS plasticity. Expand
Sevoflurane Blocks the Induction of Long-term Potentiation When Present during, but Not When Present Only before, the High-frequency Stimulation
TLDR
The hypothesis that sevoflurane blocks long-term potentiation formation only if it is present during the high-frequency stimulation is tested; this blockage of long- term potentiation does not persist if sev of lurane is discontinued before the high -frequency stimulation. Expand
Pubertal Expression of α4βδ GABAA Receptors Reduces Seizure-Like Discharges in CA1 Hippocampus
TLDR
Data suggest that α4βδ GABARs are anti-convulsant during adolescence, suggesting a mechanism for the effects of α4 βδ and α5-GABars, which exhibit different polarity-dependent desensitization. Expand
Early intervention with levetiracetam prevents the development of cortical hyperexcitability and spontaneous epileptiform activity in two models of neurotrauma in rats
TLDR
It is suggested that early administration of LEV has the potential to prevent or reduce posttraumatic epileptogenesis and that there may be a narrow therapeutic window for successful prophylactic intervention. Expand
Valproate Prevents Epileptiform Activity After Trauma in an In Vitro Model in Neocortical Slices
Purpose: Epileptogenesis is a hallmark of severe cortical trauma, with up to approximately 80% of patients experiencing seizures in the first 24 hours after penetrating head injury. An in vitro modelExpand
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