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Pancreatic cancer is a deadly disease characterized by late diagnosis and resistance to therapy. Much progress has been made in defining gene defects in pancreatic cancer, but a full accounting of its molecular pathogenesis remains to be provided. Here, we show that expression of the ataxia-telangiectasia group D complementing gene (ATDC), also called(More)
BACKGROUND Pancreatic cancer stem cells (CSCs) represent a small subpopulation of pancreatic cancer cells that have the capacity to initiate and propagate tumor formation. However, the mechanisms by which pancreatic CSCs are maintained are not well understood or characterized. METHODS Expression of Notch receptors, ligands, and Notch signaling target(More)
Mechanical elasticity of hexagonal wurtzite GaN nanowires with hexagonal cross sections grown through a vapour-liquid-solid (VLS) method was investigated using a three-point bending method with a digital-pulsed force mode (DPFM) atomic force microscope (AFM). In a diameter range of 57-135 nm, bending deflection and effective stiffness, or spring constant,(More)
Protein kinases represent the most effective class of therapeutic targets in cancer; therefore, determination of kinase aberrations is a major focus of cancer genomic studies. Here, we analyzed transcriptome sequencing data from a compendium of 482 cancer and benign samples from 25 different tissue types, and defined distinct "outlier kinases" in individual(More)
The hedgehog pathway has been implicated in the tumorigenesis, tumor progression, and metastasis of numerous human cancers. We generated the first fully human hedgehog antibody MEDI-5304 and characterized its antitumor activity and preclinical toxicology. MEDI-5304 bound sonic hedgehog (SHH) and Indian hedgehog (IHH) with low picomolar affinity and(More)
By a topological dynamical system (TDS for short) (X,f),we mean a compact metric space X together with a surjective continuous map f:X rarr X.The chaoticity of a TDS is a centrum topic of the research since the introducing the term of chaos in 1975 by Li and York, known as Li-York chaos today, and notions of sensitivity is the kernel in the definition of(More)
The operational performance of logistics is the core-competitiveness of third-party logistics (TPL) enterprise. This paper brings forward the merger theory model of system integration and system specialization, and establishes the indicator system of TPL operational performance depends on the model, and then analyses the evaluation methods and data change.(More)
Text information in natural images is very important to cross-media retrieval, index and understanding. However, its detection is challenging due to varying backgrounds, low contrast between text and non-text regions, perspective distortion and other disturbing factors. In this paper, we propose a novel text line detection method which can detect text line(More)
Adenocarcinoma of the pancreas is a lethal malignancy, and better models to study tumor behavior in vivo are needed for the development ofmore effective therapeutics. Ionizing radiation is a treatment modality that is commonly used in the clinical setting, in particular, for locally confined disease; however, good model systems to study the effect of(More)