Lidiia A Astakhova

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The involvement of proteoglycans (PGs) in EBV-host interactions and lymphomagenesis remains poorly investigated. In this study, expression of major proteoglycans (syndecan-1, glypican-1, perlecan, versican, brevican, aggrecan, NG2, serglycin, decorin, biglycan, lumican, CD44), heparan sulphate (HS) metabolic system (EXT1/2, NDST1/2, GLCE, HS2ST1, HS3ST1/2,(More)
Many and deep cyclical changes in measures of retinal functioning during the 24-h daily cycle are to a significant extent determined by the actions of two neuromodulators – melatonin and dopamine. Dopamine and melatonin form a reciprocal pair mutually inhibiting each other’s synthesis, and are released into the intercellular space of the retina essentially(More)
Until recently, it has generally been believed that cyclic AMP plays an important role in supporting circadian cycles in the vertebrate retina, but does not directly control the photoreceptors' phototransduction cascade. However, the cAMP levels in photoreceptors oscillate during the day/night cycle, and the cAMP turnover in photoreceptors may be(More)
The effect of short chain fatty acids (SCFAs) on gene expression in human, malignant cell lines was investigated, with a focus on signaling pathways. The commensal microbial flora produce high levels of SCFAs with established physiologic effects in humans. The most abundant SCFA metabolite in the human microflora is n-butyric acid. It is well known to(More)
Numerous and profound cyclical changes in retina functioning during a 24-hour daily cycle are largely determined by the influence of two neuromodulators--melatonin and dopamine. Do- pamine and melatonin form a reciprocal pair by mutually inhibiting the synthesis of each other, and they release into extracellular space of the retina approximately in(More)
Until recently, cAMP has been believed to play an important role in the organization of circadian rhythms in the vertebrate eye but not to be directly involved in controlling the phototransduction cascade in photoreceptors. However, given that cAMP levels in photoreceptor cells vary significantly during the day and that cAMP metabolism in photoreceptor(More)
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