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PURPOSE Frequently, three-dimensional (3D) conformal beams are used in lung cancer stereotactic body radiotherapy (SBRT). Recently, volumetric modulated arc therapy (VMAT) was introduced as a new treatment modality. VMAT techniques shorten delivery time, reducing the possibility of intrafraction target motion. However dose distributions can be quite(More)
Observations, numerical modeling, and theoretical calculations show how the 18.6-year modulation of the main lunar semidiurnal tide in the Bay of Fundy and Gulf of Maine is reduced from its astronomical value of 3.7 percent to 2.4 percent by the effects of friction and resonance. The agreement of the three approaches increases confidence in model(More)
PURPOSE To assess the impact of two multileaf collimator (MLC) systems (2.5 and 5 mm leaf widths) on three-dimensional conformal radiotherapy, intensity-modulated radiotherapy, and dynamic conformal arc techniques for stereotactic body radiation therapy (SBRT) of liver and lung lesions. METHODS Twenty-nine SBRT plans of primary liver (n=11) and lung(More)
Based on a recently developed variational method, we explore the properties of the Holstein polaron on an infinite lattice in D dimensions, where 1 ≤ D ≤ 4. The computational method converges as a power law, so that highly accurate results can be achieved with modest resources. We present the most accurate ground state energy (with no small parameter) to(More)
The use of physiologically based pharmacokinetic (PBPK) models has been proposed as a means of estimating the dose of the reactive metabolites of carcinogenic xenobiotics reaching target tissues, thereby affording an opportunity to base estimates of potential cancer risk on tissue dose rather than external levels of exposure. In this article, we demonstrate(More)
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