Lichuan Zhang

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This study aimed to determine the relationship between the endogenous levels of P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), lung resistance-related protein (LRP), glutathione-s-transferase-π (GST‑π) and topoisomerase IIα (TopoIIα) and intrinsic drug resistance in four human lung cancer cell lines, SK-MES-1, SPCA-1, NCI-H-460 and(More)
The upregulation of GRP78 and GRP94 under the induction of A23187 and its function in drug resistance to etoposide (VP-16) was investigated in human lung cancer cell line SK-MES-1. The expression of GRP78 and GRP94 induced by A23187 at different concentrations was analyzed by RT-PCR and Western blotting. Cell survival to VP-16 was determined using a(More)
Fibroblasts, the major cell type in tumor stroma, are essential for tumor growth and survival, and represent an important therapeutic target for cancers. Here we presented a microfluidic co-culture device in which the three-dimensional (3D) matrix was employed to reconstruct an in vivo-like fibroblast-tumor cell microenvironment for investigation of the(More)
INTRODUCTION Heavy cigarette smoking-related chronic obstructive pulmonary disease is an independent risk factor for lung squamous carcinoma. However, the mechanisms underlying the malignant transformation of bronchial epithelial cells are unclear. METHODS In our study, human tumor-adjacent bronchial epithelial cells were obtained from 10 cases with(More)
Microchip-based systems have been developed rapidly due to their desirable advantages over conventional platforms. Higher level system integration and complex microdevices are emerging to satisfy the demand for high-throughput and large-scale applications. However, most of the devices need to be fabricated with complicated microvalves and micropumps, which,(More)
In this paper, we propose a cooperative localization algorithm based on Extended Kalman Filter (EKF) for multiple underwater vehicles. Research on cooperative localization of multiple underwater vehicles is an important topic to solve the navigation problem in long range and deep sea. We investigate the improvement in navigation accuracy. In the cooperative(More)
BACKGROUND AND OBJECTIVE Hsp90 is a major molecular chaperone, which overexpression is involved in oncogenesis, development and drug resistance in many human cancers. The aim of this study is to investigate the relationship between the GGA-induced overexpression of Hsp90 and chemoresistance to Cisplatin in SPCA-1 and H446 cell line. METHODS The protein(More)
The optimization process of concurrent subspace design (CSD) algorithm is reviewed in details. The study is carried out in the framework of the shape design of autonomous underwater vehicle (AUV), and which is divided into two disciplines, i.e., low drag design and low noise design. A multiobjective, multidisciplinary design optimization (M&MDO) model(More)
A ballistic missile is one of the main targets of space target defense and often has an established trajectory. As the target, we are only interested in its trajectory. The intercepting missile, as a defense body, controls itself toward the target according to the target state observed information and the control strategies in real time. So, the kinematic(More)
BACKGROUND AND OBJECTIVE The expression levels of glucose-regulated protein 78 (GRP78) were elevated and correlated with resistance to chemotherapy drug VP-16 in lung cancer cells. However, little is known about the relationship between its expression and resistance to cisplatin in lung cancer cells. The aim of this study was to investigate the expression(More)