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The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells.
It is found that upregulation of Bmi-1 induced epithelial-mesenchymal transition (EMT) and enhanced the motility and invasiveness of human nasopharyngeal epithelial cells, whereas silencing endogenous Bmi -1 expression reversed EMT and reduced motility.
Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.
It is reported that loss of one copy of Gls blunted tumor progression in an immune-competent MYC-mediated mouse model of hepatocellular carcinoma and small molecule and genetic inhibition of GLS are supported for targeting the tumor cell-autonomous dependence on GLS for cancer therapy.
Astrocyte Elevated Gene-1 is a Novel Prognostic Marker for Breast Cancer Progression and Overall Patient Survival
The results suggest that AEG-1 protein is a valuable marker of breast cancer progression, and high A EG-1 expression is associated with poor overall survival in patients with breast cancer.
Unregulated miR-96 Induces Cell Proliferation in Human Breast Cancer by Downregulating Transcriptional Factor FOXO3a
It is suggested that miR-96 may play an important role in promoting proliferation of human breast cancer cells and present a novel mechanism of miRNA-mediated direct suppression of FOXO3a expression in cancer cells.
Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells.
This study provides the first cellular proto-oncogene immortalized nasopharyngeal epithelial cell line, which may serve as a cell model system for studying the mechanisms involved in the tumorigenesis of nasopharygeal carcinoma.
Sam68 up‐regulation correlates with, and its down‐regulation inhibits, proliferation and tumourigenicity of breast cancer cells
Sam68, an RNA‐binding protein that links cellular signalling to RNA processing, was markedly overexpressed in breast cancer cells and tissues and might be a novel and useful prognostic marker and a potential target for human breast cancer treatment.
Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer
The repression of Bmi-1 in highly metastatic breast cancer cells remarkably reduces cellular motility, invasion and transformation, as well as tumorigenesis and lung metastases in nude mice.
miR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-β.
Overexpression of GOLPH3 Promotes Proliferation and Tumorigenicity in Breast Cancer via Suppression of the FOXO1 Transcription Factor
The results suggest that high GOLPH3 expression is associated with poor overall survival in patients with breast cancer and that GolPH3 overexpression increases the proliferation and tumorigenicity of human breast cancer cells.