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With the publication of the sequence of the human genome, we are challenged to identify the functions of an estimated 70,000 human genes and the much larger number of proteins encoded by these genes. Of particular interest is the identification of gene products that play a role in human disease pathways, as these proteins include potential new targets that(More)
RNA interference is a powerful tool for studying gene function and for drug target discovery in diverse organisms and cell types. In mammalian systems, small interfering RNAs (siRNAs), or DNA plasmids expressing these siRNAs, have been used to down-modulate gene expression. However, inefficient transfection protocols, in particular, for primary cell types,(More)
This review aims to summarize the evidence that Notch signaling is associated with prostate development, tumorigenesis and prostate tumor progression. Studies in PubMed database were searched using the keywords of Notch signaling, prostate development and prostate cancer. Relevant literatures were identified and summarized. The Notch pathway plays an(More)
OBJECTIVE To explore the relationship between urolithiasis and related factors by chemical analysis of urolithic components in the urine and serum of Uigurs and Han in Xingjiang. MATERIALS AND METHODS A series of 251 inpatients' urinary calculi (Uigurs: 148; Han: 103) were qualitatively chemically analyzed. Their serum and urine biochemistry was(More)
In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: a b s t r a c t In this paper, we consider the properties of monotonicity-preserving(More)
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