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MiR-204-5p suppresses cell proliferation by inhibiting IGFBP5 in papillary thyroid carcinoma.
Emerging roles for PIWI proteins in cancer.
TLDR
PIWI proteins are linked to the hallmarks of cancer defined by Weinberg and Hanahan, such as cell proliferation, anti-apoptosis, genomic instability, invasion and metastasis, which provides new possibilities for anticancer therapies through the targeting of PIWI proteins.
Gene expression changes in human mesenchymal stem cells from patients with osteoporosis
TLDR
The DEGs with high degree in the PPI and transcriptional regulatory networks may be candidate target molecules, which may be used to monitor, diagnose and treat osteoporosis.
miR-486-5p inhibits cell growth of papillary thyroid carcinoma by targeting fibrillin-1.
Existing bitter medicines for fighting 2019‐nCoV‐associated infectious diseases
TLDR
It is suggested that a cocktail‐like recipe of existing bitter drugs may help doctors to fight this catastrophic disease and that the general public may drink or eat bitter substances, such as coffee, tea, or bitter vegetables, to reduce the risk of infection.
Quantitative Assessment of Common Genetic Variants on FOXE1 and Differentiated Thyroid Cancer Risk
TLDR
It is demonstrated that common variations of FOXE1 are a risk factor associated with increased TC susceptibility and heterogeneity largely disappeared after stratification by ethnicity.
Common Variants on Cytotoxic T Lymphocyte Antigen-4 Polymorphisms Contributes to Type 1 Diabetes Susceptibility: Evidence Based on 58 Studies
TLDR
It is demonstrated that the G49A and C60T polymorphism of CTLA4 is a risk factor associated with increased T1D susceptibility, but these associations vary in different ethnic populations.
17β-estradiol attenuates ovariectomy-induced bone deterioration through the suppression of the ephA2/ephrinA2 signaling pathway
TLDR
E2 can attenuate OVX-induced bone deterioration partially through the suppression of the ephA2/ephrinA2 signaling pathway, which may be a potential target for osteoporosis treatment.
Rediscovery of caffeine: an excellent drug for improving patient outcomes while fighting WARS.
TLDR
It is found that caffeine can fight WARS by acting on multiple organs, which may lead to prevent the virus from entering the cell, stimulate the phagocytosis of macrophages, enhance breathing, and inhibit the cytokine storm.
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