Lianshun Jia

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UNLABELLED Following peripheral nerve injury (PNI) microglia proliferates and adopts inflammation that contributes to development and maintenance of neuropathic pain. miRNAs and autophagy are two important factors in the regulation of inflammation. However, little is known about whether miRNAs regulate neuroinflammation and neuropathic pain by controlling(More)
Eosinophilic granuloma (EG) of the spine is rare, especially in adults. There had been few large and long-term studies reported in the literature. The management goals of this disease in adults are preservation of neurologic function, relief of pain and reconstruction of spinal stability. However, there are still controversies over appropriate management(More)
BACKGROUND CONTEXT Thoracic myelopathy caused by multilevel (three or more levels) ossification of the ligamentum flavum (OLF) is rare. Little is known about its clinical features, and the surgical outcomes along with its related factors are also unclear. PURPOSE To describe the clinical features, assess the safety and effectiveness of surgical(More)
BACKGROUND Surgical approaches for cervical ossification of the posterior longitudinal ligament (OPLL) include anterior, posterior, or combined decompression with or without fusion. The goal of surgery is to decompress the spinal cord while maintaining the stability and sagittal alignment of the cervical spine. C5 palsy has been reported as a postoperative(More)
OBJECT To date, formulation of the optimal surgical protocol for noncontiguous multilevel cervical spondylosis remains controversial, and the corresponding clinical data continue to be limited. The purpose of this study was to compare the clinical and radiological outcomes of two hybrid reconstructive techniques in noncontiguous 3-level cervical spondylosis(More)
STUDY DESIGN A retrospective review study. OBJECTIVES To estimate the clinical outcome of various resection protocols in patients with chondrosarcoma (CHS) at the challenging region of cervical and cervicothoracic spine (CCT). SUMMARY OF BACKGROUND DATA It is challenging to surgically manage CHS of the spine. Although total en-bloc resection has proven(More)
STUDY DESIGN Primary clinical trial of limited fixation for unstable Atlas fracture. OBJECTIVES To clinically validate feasibility, safety and value of the C1 later-mass screw C2 pedicle screw and crosslink compression fixation technique. SUMMARY OF BACKGROUND DATA [corrected] In previous clinical studies, several techniques have been introduced to fix(More)
It is increasingly clear that microRNAs (miRNAs) play an important role in controlling cell survival. However, the functional significance of miRNAs in ischemic brain injury remains poorly understood. In the present study, we assayed the expression levels of miR-29b after ischemic brain injury, and defined the target genes and biological functions of(More)
STUDY DESIGN A retrospective clinical study of 64 patients who underwent anterior cervical discectomy and fusion (ACDF) with BAK/C for disc degenerative disorders. OBJECTIVE To evaluate the long-term outcome of BAK/C in the treatment of cervical disc degenerative disorders. SUMMARY OF BACKGROUND DATA ACDF has been demonstrated to be effective in the(More)
STUDY DESIGN The clinical and radiologic results of the patients with removed posterior longitudinal ligament (PLL) were compared with those of the patients with preserved PLL in the treatment of cervical spondylotic myelopathy (CSM). OBJECTIVE To investigate effect of resection of the PLL in anterior decompression for CSM. SUMMARY OF BACKGROUND DATA(More)