Lianne Rotin

Learn More
DNA copy-number variations (CNVs) underlie many neuropsychiatric conditions, but they have been less studied in cancer. We report the association of a 17p13.1 CNV, childhood-onset developmental delay (DD), and cancer. Through a screen of over 4000 patients with diverse diagnoses, we identified eight probands harboring microdeletions at TP53 (17p13.1). We(More)
Sonic Hedgehog and its GLI transcriptional effectors control foliation complexity during cerebellar morphogenesis by promoting granule cell precursor proliferation. Here, we reveal a novel contribution of Sonic Hedgehog-GLI signaling to cerebellar patterning and cell differentiation by generating mice with targeted deletion of Suppressor of Fused (SuFu), a(More)
  • L. Ya. Rotin
  • Bulletin of Experimental Biology and Medicine
  • 2004
The formation of senile plaques is interpreted by some workers as necrobiosis [2, 3, 20], by others as the precipitat ion of certain substances [4, 8, 18], and by a third group as the result of deposition of metabolic products [1, 6, 13, 14]. Some invest igators associate the formation of senile plaques with amyloidosis [5, 7, 9, 10, 17, 19]. The(More)
  • L. Ya. Rotin
  • Bulletin of Experimental Biology and Medicine
  • 2004
Changes in the neurofibri ls charac te r i s t i c of A lzhe imer ' s disease are frequently found in cort ical neurons of old persons. However, they are discovered most constantly in A lzhe imer ' s disease i tself and in senile dementia. Different views are expressed on the nature of this unique metamorphosis of nerve cells: thickening of the neurofibri(More)
  • 1