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Fanconi Anemia Complementation Group A (FANCA) Protein Has Intrinsic Affinity for Nucleic Acids with Preference for Single-stranded Forms*
Background: The FANCA (Fanconi anemia complementation group A) gene is mutated in ∼60% of Fanconi anemia patients, but no biochemical activity has been identified. Results: Purified FANCA binds toExpand
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Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks.
The Y-family of DNA polymerases support of translesion DNA synthesis (TLS) associated with stalled DNA replication by DNA damage. Recently, a number of studies suggest that some specialized TLSExpand
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Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA*
Background: 3′ repair exonuclease 1 (TREX1) is a DNase involved in autoimmune disorders and the antiviral response. Results: TREX1 also degrades single-stranded RNA or RNA in a RNA/DNA hybridExpand
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Assembling an orchestra: Fanconi anemia pathway of DNA repair.
Fanconi anemia (FA) is a recessive genetic disorder characterized by developmental defects, bone marrow failure, and cancer susceptibility. The complete set of FA genes has only been identifiedExpand
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Damage-dependent regulation of MUS81-EME1 by Fanconi anemia complementation group A protein
MUS81-EME1 is a DNA endonuclease involved in replication-coupled repair of DNA interstrand cross-links (ICLs). A prevalent hypothetical role of MUS81-EME1 in ICL repair is to unhook the damage byExpand
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Human Fanconi Anemia Complementation Group A Protein Stimulates the 5’ Flap Endonuclease Activity of FEN1
In eukaryotic cells, Flap endonuclease 1 (FEN1) is a major structure-specific endonuclease that processes 5’ flapped structures during maturation of lagging strand DNA synthesis, long patch baseExpand
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Assembling an orchestra: Fanconi anemia pathway of DNA repair.
Abstract Fanconi anemia (FA) is a recessive genetic disorder characterized by developmental defects, bone marrow failure, and cancer susceptibility. The complete set of FA genes has only beenExpand
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Abstract 1286: FANCA binds to nucleic acids and stimulates endonuclease activity of FEN1.
Fanconi anemia is a rare autosomal recessive or X-linked genetic disease characterized by progressive bone marrow failure, various developmental anomalies, and cancer predisposition. Fanconi anemiaExpand