Liangliang Zhong

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MERTK plays an important role in cell biology and is correlated with many cancers, such as mantle cell lymphomas, pituitary adenomas, and T-cell acute lympholoblastic leukemia. So identification of new MERTK inhibitors is of extreme importance. In this study, 107 MERTK inhibitors with known activities were gathered to generate a ligand-based pharmacophore(More)
Li Zongmin, Wang Daqian ,Li Boyang, Zhong Liangliang (School of Computer Science and Communication Engineering, China University of Petroleum, Donying 257061, China) Abstract: In 3D model retrieval area, many methods have been proposed. However, most of these methods are content-based, and focus on how to describe a model more accurately and how to measure(More)
In this paper, we present a video based detection framework for Intelligent Transportation System. We combine the invariant color features with GMM background model to eliminate shadows and highlighted background regions during moving object segmentation. Then we provide a novel global motion detector to detect camera motions. Finally, we introduce a lane(More)
AIM AND OBJECTIVE Anaplastic lymphoma kinase, an insulin receptor protein-tyrosine kinase, is a very attractive receptor protein target for anticancer therapy. This study was undertaken to identify novel structurally diverse anaplastic lymphoma kinase inhibitors. MATERIAL AND METHOD Pharmacophore hypotheses modeling, virtual screening and molecular(More)
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