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Tandem 3' untranslated regions (UTRs), produced by alternative polyadenylation (APA) in the terminal exon of a gene, could have critical roles in regulating gene networks. Here we profiled tandem poly(A) events on a genome-wide scale during the embryonic development of zebrafish (Danio rerio) using a recently developed SAPAS method. We showed that 43% of(More)
Increasing amounts of genes have been shown to utilize alternative polyadenylation (APA) 3'-processing sites depending on the cell and tissue type and/or physiological and pathological conditions at the time of processing, and the construction of genome-wide database regarding APA is urgently needed for better understanding poly(A) site selection and(More)
The human brain atlases that allow correlating brain anatomy with psychological and cognitive functions are in transition from ex vivo histology-based printed atlases to digital brain maps providing multimodal in vivo information. Many current human brain atlases cover only specific structures, lack fine-grained parcellations, and fail to provide(More)
Alpine ecosystems are highly sensitive to global climate changes. The Tibetan Plateau is one of the areas that are most sensitive to global climate change. Increases in temperature and changes in precipitation can impact the plateau's ecosystem productivity. Net primary productivity (NPP) is one of the most important factors in the carbon cycle of(More)
BACKGROUND Diffusion magnetic resonance imaging (dMRI) techniques are receiving increasing attention due to their ability to characterize the arrangement map of white matter in vivo. However, the existing toolkits for dMRI analysis that have accompanied this surge possess noticeable limitations, such as large installation size, an incomplete pipeline, and a(More)
Characterizing spatial and temporal variations of PM pollution is critical for a thorough understanding of its formation, transport and accumulation in the atmosphere. In this study, Aerosol Optical Thickness (AOT) data retrieved from a Moderate Resolution Imaging Spectroradiometer (MODIS) were used to investigate the spatial and temporal variations of PM(More)