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Mutations in CHEK2 associated with prostate cancer risk.
TLDR
The data suggest that mutations in CHEK2 may contribute to prostate cancer risk and that the DNA-damage-signaling pathway may play an important role in the development of prostate cancer. Expand
BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair.
TLDR
BRAF mutations occurred rarely in tumors with defective mismatch repair attributable to the presence of germ-line mutation in either hMLH1 or hMSH2, and these data suggest that BRAF mutations are not a consequence of defective mismatchrepair per se. Expand
Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states
TLDR
Examination of the genomic regions containing differentially expressed miRNAs revealed that they were also differentially methylated in colon cancer at a far greater rate than would be expected by chance. Expand
MYH mutations in patients with attenuated and classic polyposis and with young-onset colorectal cancer without polyps.
TLDR
Screening of MYH should be considered not only in patients with multiple polyps but also in patientsWith early-onset CRC, where 2 of the 116 individuals with CRC diagnosed at 50 years of age or younger also presented with biallelic germline mutations in MYH. Expand
CircHIPK3 sponges miR‐558 to suppress heparanase expression in bladder cancer cells
TLDR
It is shown that circHIPK3, also named bladder cancer‐related circular RNA‐2 (BCRC‐2), is significantly down‐regulated in bladder cancer tissues and cell lines, and negatively correlates with bladder cancer grade, invasion as well as lymph node metastasis, respectively. Expand
Analysis of the RNASEL gene in familial and sporadic prostate cancer.
TLDR
It is suggested that polymorphic changes within the RNASEL gene may be associated with increased risk of familial but not sporadic PC. Expand
Language Identification: A Tutorial
TLDR
This tutorial presents an overview of the progression of spoken language identification (LID) systems and current developments, and Evaluations of the LID system are presented using NIST language recognition evaluation tasks. Expand
Evaluation of Genetic Variations in the Androgen and Estrogen Metabolic Pathways as Risk Factors for Sporadic and Familial Prostate Cancer
TLDR
The hypothesis that common genetic variations for those enzymes involved in the androgen and estrogen metabolic pathways increase risk for sporadic and familial prostate cancer was tested and none of the findings were statistically significant after appropriate corrections for multiple comparisons. Expand
Genome-wide association and replication studies identified TRHR as an important gene for lean body mass.
TLDR
Results of this study support the TRHR gene as an important gene for LBM variation, together with the functional relevance of TRHR in muscle metabolism, by using Affymetrix 500K single-nucleotide polymorphism (SNP) arrays. Expand
Long non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway
TLDR
Observations imply that the NEAT1 modulated the expression of E2F3 gene by acting as a ceRNA, which may build up the missing link between the regulatory miRNA network and NSCLC progression. Expand
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