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BACKGROUND The present study examined whether aerobic fitness training of older humans can increase brain volume in regions associated with age-related decline in both brain structure and cognition. METHODS Fifty-nine healthy but sedentary community-dwelling volunteers, aged 60-79 years, participated in the 6-month randomized clinical trial. Half of the(More)
Deterioration of the hippocampus occurs in elderly individuals with and without dementia, yet individual variation exists in the degree and rate of hippocampal decay. Determining the factors that influence individual variation in the magnitude and rate of hippocampal decay may help promote lifestyle changes that prevent such deterioration from taking place.(More)
Over the next 20 years the number of Americans diagnosed with dementia is expected to more than double (CDC, 2007). It is, therefore, an important public health initiative to understand what factors contribute to the longevity of a healthy mind. Both default mode network (DMN) function and increased aerobic fitness have been associated with better cognitive(More)
Chromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L) is a recently identified oncogene localized at 1q21, a frequently amplified region in hepatocellular carcinoma (HCC). To explore its oncogenic mechanisms, we set out to identify CHD1L-regulated genes using a chromatin immunoprecipitation-based (ChIP-based) cloning strategy in a human HCC(More)
Collaborative filtering (CF) is a major technique in recommender systems to help users find their potentially desired items. Since the data sparsity problem is quite commonly encountered in real-world scenarios, Cross-Domain Collaborative Filtering (CDCF) hence is becoming an emerging research topic in recent years. However, due to the lack of sufficient(More)
– Collaborative ad-hoc dissemination of information has been proposed as an efficient means to disseminate information among devices in a wireless ad-hoc network. Devices help in forwarding the information channels to the entire network, by disseminating the channels they subscribe to, plus others. We consider the case where devices have a limited amount of(More)
OBJECTIVE To examine the contribution of social-cognitive factors (self-efficacy and affect) in predicting long-term physical activity in a sample of older adults (N=174). DESIGN A prospective design assessed physical activity and psychosocial variables at 2 and 5 years following a 6-month randomized, controlled exercise trial. MAIN OUTCOME MEASURES The(More)
The Internet of Things (IoT) implies a worldwide network of interconnected objects uniquely addressable, via standard communication protocols. The prevalence of IoT is bound to generate large amounts of multisource, heterogeneous, dynamic, and sparse data. However, IoT offers inconsequential practical benefits without the ability to integrate, fuse, and(More)
Accurate grid resources prediction is crucial for a grid scheduler. In this study, support vector regression (SVR), which is an effective regression algorithm, is applied to grid resource prediction. In order to obtain better prediction performance, SVR’s parameters must be selected carefully. Therefore, a particle swarm optimization-based SVR(More)