Liang Hong

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Amyloid-beta (Abeta) peptide is the original causative factor of Alzheimer's disease (AD) according to the amyloid cascade hypothesis. The ubiquitin-proteasome system (UPS), the major intracellular protein quality control system in eukaryotic cells, is related to AD pathogenesis. There is growing evidence showing that there is a tight relationship between(More)
Voltage-gated sodium, potassium, and calcium channels are made of a pore domain (PD) controlled by four voltage-sensing domains (VSDs). The PD contains the ion permeation pathway and the activation gate located on the intracellular side of the membrane. A large number of small molecules are known to inhibit the PD by acting as open channel blockers. The(More)
—The WindSat microwave polarimetric radiometer consists of 22 channels of polarized brightness temperatures op-(vertical/horizontal, 45 and left-hand and right-hand circularly polarized) to measure the four Stokes radiometric parameters. The principal objective of this Naval Research Laboratory experiment, which flys on the USAF Coriolis satellite, is to(More)
Orientation-dependent interactions can drive unusual self-assembly of colloidal particles. This study, based on combined epifluorescence microscopy and Monte Carlo simulations, shows that amphiphilic colloidal spheres, hydrophobic on one hemisphere and charged on the other, assemble in water into extended structures not formed by spheres of uniform surface(More)
We study the assembly of spherical particles with opposite electric charge on both hemispheres, in the case that the particle diameter exceeds the electrostatic screening length. Clusters result, not strings. The cluster shapes are analyzed by combined epifluorescence microscopy and Monte Carlo computer simulations with excellent agreement, indicating that(More)
Play-on-demand is usually regarded as a feasible access mode for web content (including streaming video, web pages and so on), web services and some Software-As-A-Service (SaaS) applications, but not for common desktop applications. This paper presents such a solution for Windows desktop-applications based on lightweight virtualization and network(More)