• Publications
  • Influence
Dual Targeting of HER2-Positive Cancer with Trastuzumab Emtansine and Pertuzumab: Critical Role for Neuregulin Blockade in Antitumor Response to Combination Therapy
Purpose: Targeting HER2 with multiple HER2-directed therapies represents a promising area of treatment for HER2-positive cancers. We investigated combining the HER2-directed antibody–drug conjugateExpand
  • 130
  • 9
  • PDF
Hydrodynamic Lubrication of Microdimple Textured Surface Using Three-Dimensional CFD
Surface texturing has been recognized to be very efficient in modifying the tribological performances of sliding surfaces. In the present article, a three-dimensional hydrodynamic lubrication modelExpand
  • 93
  • 5
Time dependence of the enhancement effect of chemical enhancers: Molecular mechanisms of enhancing kinetics
Abstract Chemical enhancers are widely used for facilitating drug penetration in transdermal drug delivery system (TDDS). However, there is a lack of knowledge about how the enhancement effectExpand
  • 31
  • 3
The Control of Skin-Permeating Rate of Bisoprolol by Ion-Pair Strategy for Long-Acting Transdermal Patches
A moderate drug permeating rate (flux) is desirable for long-acting transdermal patches. In this work, a novel simple method of controlling bisoprolol (BSP) flux by ion-pair strategy was initiated.Expand
  • 18
  • 3
Correlation Between Rheological Properties, In Vitro Release, and Percutaneous Permeation of Tetrahydropalmatine
The aim of the present work was to investigate the influence of formulation factors including different grades of Carbopol® matrices and penetration enhancers on the percutaneous permeation ofExpand
  • 33
  • 3
Eukaryotic Translation Initiation Factor 3b is both a Promising Prognostic Biomarker and a Potential Therapeutic Target for Patients with Clear Cell Renal Cell Carcinoma
Eukaryotic translation initiation factors (eIFs) constitute a new class of therapeutic cancer targets. EIF3b is the major scaffold protein of eIF3 (the largest core of eIFs). We sought to define theExpand
  • 19
  • 3
  • PDF
Microbiota Modulate Anxiety-Like Behavior and Endocrine Abnormalities in Hypothalamic-Pituitary-Adrenal Axis
  • Ran Huo, B. Zeng, +10 authors P. Xie
  • Biology, Medicine
  • Front. Cell. Infect. Microbiol.
  • 30 November 2017
Intestinal microbes are an important system in the human body, with significant effects on behavior. An increasing body of research indicates that intestinal microbes affect brain function andExpand
  • 48
  • 2
Design and in vivo evaluation of an indapamide transdermal patch.
The aim of the present study was to develop and evaluate a novel drug-in-adhesive transdermal patch system for indapamide. Initial in vitro experiments were conducted to optimize formulationExpand
  • 67
  • 2
Lipid-based liquid crystalline nanoparticles as oral drug delivery vehicles for poorly water-soluble drugs: cellular interaction and in vivo absorption
Background Lipid-based liquid crystalline nanoparticles (LCNPs) have attracted growing interest as novel drug-delivery systems for improving the bioavailability of both hydrophilic and hydrophobicExpand
  • 60
  • 2
  • PDF
Effect of O-acylmenthol on transdermal delivery of drugs with different lipophilicity.
To develop more effective compounds as enhancers, O-acylmenthol derivatives which were expected to be enzymatically hydrolyzed into nontoxic metabolites by esterases in the living epidermis wereExpand
  • 23
  • 2