BACKGROUND Parkinson's disease (PD) is affecting 5 million people worldwide, but the response mechanisms of the striatum are still unclear. Therefore, identification of gene expression alterations in the striatum will greatly assist the development of novel therapy strategies. METHODS We performed a comprehensive gene expression analysis in 15 PD patients… (More)
Chronic hypoxia has been reported to contribute to the development of Alzheimer’s disease (AD). However, the mechanism of hypoxia in the pathogenesis of AD remains unclear. The purpose of this study was to investigate the effects of chronic hypoxia treatment on β-amyloid, tau pathologies, and the behavioral consequences in the double transgenic (APP/PS1)… (More)
Retraction The Publisher and Editor regretfully retract this article  because the peer-review process was inappropriately influenced and compromised. As a result, the scientific integrity of the article cannot be guaranteed. A systematic and detailed investigation suggests that a third party was involved in supplying fabricated details of potential peer… (More)
To investigate the genetic association of 5-HTTLPR polymorphism and Parkinson’s disease (PD) or depression in PD by using meta analysis. Published association studies on genotype or allele frequencies of the 5-HTTLPR in patients with or without PD or in PD patients with or without depression in all ethnic groups were included. A biallelic meta-analysis,… (More)
This paper is concerned with a problem of maximizing the sum of several ratios of functions. We extend an algorithm, which has been designed to solve the sum-of-linear-ratios problem, for solving the sum-of-nonlinear-ratios problem. We also discuss the complexity of the problem and report the results of numerical experiments on the extended algorithm.