Liana Lisboa Fernandez

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Oxidative stress, cellular damage, and neuronal apoptosis are believed to underlie the progressive cognitive decline that accompanies natural aging and to be exacerbated in neurodegenerative diseases. Over the years, we have consistently demonstrated that iron neonatal treatment induces oxidative stress and memory deficits in adult rats, but the mechanisms(More)
This study was aimed to investigate neuropathological changes in adult and aged rats subjected to supplementary iron administration in a critical postnatal period to study the contribution of environmental risk factors to the pathogenesis of neurodegenerative disorders. Ten rats received a single daily oral administration of iron (10 mg/kg) between 12th and(More)
BACKGROUND The role of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms as risk factors for the occurrence of Alzheimer's disease (AD) is still controversial. OBJECTIVE To verify the association between MTHFR and apolipoprotein E (APOE) polymorphisms and Alzheimer's disease. METHOD This work was conducted as a case-control study. Cases(More)
The present study was aimed to investigate neuropathological changes in AbetaPP/PS1 transgenic mice (Tg), as a model of Alzheimer's disease, subjected to supplementary iron administration in a critical postnatal period, in order to reveal the interaction of genetic and environmental risk factors in the pathogenesis of the disease. Twelve Tg and 10 wild-type(More)
Twelve brains of individuals with more than sixty-five years were studied. These samples were submitted to three techniques, with the objective to detect senile plaques which the major component was the beta-amyloid; beta-amyloid immunohistochemistry; Glees technique; and haematoxilin-eosin technique. We detected significant differences between the number(More)
With the increase in life expectancy in Brazil, concerns have grown about the most prevalent diseases in elderly people. Among these diseases are neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. Protein deposits related to the development of these diseases can pre-date the symptomatic phases by years. The tau protein is particularly(More)
As diversas faces da síndrome demencial: como diagnosticar clinicamente? The several faces of dementia syndrome: How to diagnose clinically? ABSTRACT Aims: This review describes the clinical aspects related to different dementia syndromes, aiming to become common in the medical field, the knowledge of the nuances that permeate the differential diagnosis of(More)
The authors observed 24 children that are studying for the first time in the first grade of the elementary school. They were observed through the classical neurological examination, the evolutive neurological examination and through tests for evaluation of cortical functions. It is analyzed the school performance in report to the evolutive neurological(More)
FOXP2 is altered in a variety of language disorders. We found reduced mRNA and protein expression of FOXP2 in frontal cortex area 8 in Pick's disease, and frontotemporal lobar degeneration-tau linked to P301L mutation presenting with language impairment in comparison with age-matched controls and cases with parkinsonian variant progressive supranuclear(More)
Conclusões: a revisão da literatura sugere que o estresse oxidativo, associado ao desequilíbrio na homeostase do ferro, seja uma via importante em relação à patogênese da neurodegeneração. Esses dados requerem novas investigações para esclarecer se este desequilíbrio é causa ou conseqüência do processo neurodegenerativo. ABSTRACT Aims: Increasing evidence(More)