Lian-hong Zhou

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OBJECTIVE To explore whether recombinant adeno-associated virus mediated antisense vascular endothelial growth factor (rAAV-aVEGF) gene transfer inhibits the development of corneal neovascularization (CNV) in a rat model. METHODS rAAV-aVEGF(165) and recombinant adeno-associated virus mediated Lacz (rAAV-Lacz) were constructed by three-plasmid(More)
OBJECTIVE To evaluate visual development after extraction of congenital cataract in young patients. METHODS This was a retrospective clinical study. Forty one congenital cataract patients (62 eyes) at 0-3 years old were divided into 4 groups: <0.5 year old, > or =0.5 and <1 year old, > or =1 and <2 years old and > or =2 years old. Capsulectomy and(More)
Corneal transplantation is one of the most common and successful transplant surgeries performed around the world. However, the high-risk corneal transplantation remains a high level of corneal graft failure. Gene transfer of immunomodulatory molecules is considered as one potential strategy in preventing allograft rejection. It is worthy evaluating the(More)
OBJECTIVE To identify TUBB3 gene mutations in a Chinese family with congenital fibrosis of the extraocular muscle associated with corpus callosum agenesis. METHODS We have found a family with CFEOM associated with corpus callosum agenesis, including 4 affected individuals in three generations of 11 familial members. 4 affected individuals were sequenced(More)
OBJECTIVE The aim of this article was to investigate the structural basis of ocular motility and visual abnormalities in humans with congenital fibrosis of the extraocular muscles (CFEOM). METHODS 17 volunteers from 2 CFEOM pedigrees Clinical ophthalmic and motility examed and 18 normal control subjects were correlated with thin-sectioned magnetic(More)
OBJECTIVE To investigate the development of the refractive status in premature infants full-term children aged 0 to 6 years old. METHOD Case control study. One thousand one hundred and sixtyfour premature infants and One thousand one hundred and ninety-one full-term children were collected from September 2011 to September 2012 in Renmin Hospital of Wuhan(More)
OBJECTIVE To clinically characterize a collected family of congenital fibrosis of extraocular muscles associated with naso-sinusitis, then determine the genetic location of the disease gene by linkage analysis to approach the etiopathogenesis of CFEOM on gene. METHODS A CFEOM family (fifteen cases suffering from congenital general fibrosis syndrome in(More)
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