Lian-Pin Hwang

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Glioblastoma multiforme (GBM) is one of the most challenging diseases to treat in clinical oncology due to its high mortality rates and inefficient conventional treatment methods. Difficulties with early detection, post-surgical recurrences, and resistance to chemotherapy and/or radiotherapy are important reasons for the poor prognosis of those with GBM.(More)
We introduce a new category of nanoparticle-based T(1) MRI contrast agents (CAs) by encapsulating paramagnetic chelated gadolinium(III), i.e., Gd(3+)·DOTA, through supramolecular assembly of molecular building blocks that carry complementary molecular recognition motifs, including adamantane (Ad) and β-cyclodextrin (CD). A small library of(More)
A single-sided mobile NMR apparatus with a small Halbach magnet was constructed for the first time. It is lightweight, compact and exhibits good sensitivity. The weight of the device is only 2 kg, and the NMR signal of the pencil eraser block can be detected in one shot using the device. This study describes the characteristics of this instrument, including(More)
Developing novel multifunctional nanoparticles (NPs) with robust preparation, low cost, high stability, and flexible functionalizability is highly desirable. This study provides an innovative platform, termed unibody core-shell (UCS), for this purpose. UCS is comprised of two covalent-bonded polymers differed only by the functional groups at the core and(More)
This study presents a simple design for a mobile, single-sided nuclear magnetic resonance (NMR) apparatus which uses the magnetic flux parallel to the magnetization direction of a single, disc-shaped permanent magnet polarized in radial direction. The stray magnetic field above the magnet is approximately parallel to the magnetization direction of the(More)
Accurate temperature measurement is a requisite for obtaining reliable thermodynamic and kinetic information in all NMR experiments. A widely used method to calibrate sample temperature depends on a secondary standard with temperature-dependent chemical shifts to report the true sample temperature, such as the hydroxyl proton in neat methanol or neat(More)
The crystal structures of the dimer form of copper(II) tetraphenylporphyrin N-oxide, [Cu(tpp-N-O)]2 (3-dimer), and zinc(II) tetraphenylporphyrin N-oxide, [Zn(tpp-N-O)]2 (4-dimer), were established. The geometry at the copper ion in 3-dimer is essentially square-pyramidal with one oxygen bridge [O(1A)] occupying the apical site, giving a much larger Cu-O(More)
Double-quantum-filtered NMR and T(1) inversion-recovery spectroscopy were employed to exploit the temperature-dependent dynamics of D(2)O confined in MCM-41. Samples with three pore sizes of 1.58, 2.03, and 2.34 nm and two D(2)O contents were investigated. The reorientation correlation times of confined D(2)O in variously sized pores exhibit different(More)
The crystal structures of N-benzamido-meso-tetraphenylporphyrin (NHCOC(6)H(5)-Htpp; 1), (N-benzimido-meso-tetraphenylporphyrinato)(methanol)zinc(II) [Zn(N-NCOC(6)H(5)-tpp)(MeOH); 2(MeOH)], and (acetato)(N-benzamido-meso-tetraphenylporphyrinato)cadmium(II) [Cd(N-NHCOC(6)H(5)-tpp)(OAc); 3] were established. The coordination sphere around Zn(2+) ion in 2(MeOH)(More)