Lian-Pin Hwang

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Glioblastoma multiforme (GBM) is one of the most challenging diseases to treat in clinical oncology due to its high mortality rates and inefficient conventional treatment methods. Difficulties with early detection, post-surgical recurrences, and resistance to chemotherapy and/or radiotherapy are important reasons for the poor prognosis of those with GBM.(More)
We introduce a new category of nanoparticle-based T(1) MRI contrast agents (CAs) by encapsulating paramagnetic chelated gadolinium(III), i.e., Gd(3+)·DOTA, through supramolecular assembly of molecular building blocks that carry complementary molecular recognition motifs, including adamantane (Ad) and β-cyclodextrin (CD). A small library of(More)
A single-sided mobile NMR apparatus with a small Halbach magnet was constructed for the first time. It is lightweight, compact and exhibits good sensitivity. The weight of the device is only 2 kg, and the NMR signal of the pencil eraser block can be detected in one shot using the device. This study describes the characteristics of this instrument, including(More)
Developing novel multifunctional nanoparticles (NPs) with robust preparation, low cost, high stability, and flexible functionalizability is highly desirable. This study provides an innovative platform, termed unibody core-shell (UCS), for this purpose. UCS is comprised of two covalent-bonded polymers differed only by the functional groups at the core and(More)
In this study, spin-locking techniques were added as a part of intermolecular multiple-quantum experiments, thereby introducing the concept of rotating-frame intermolecular double-quantum spin-lattice relaxation, T(1rho, DQC). A novel magnetic resonance imaging methodology based on intermolecular multiple-quantum coherences is demonstrated on a 7.05-T(More)
In this paper, signals originating from a pure specific coherence of intermolecular three-spin orders were separated and characterized experimentally in highly polarized two-component spin systems. A modified CRAZED sequence with selective radio-frequency excitation was designed to separate the small signals from the strong conventional single-spin(More)
Double-quantum-filtered NMR and T(1) inversion-recovery spectroscopy were employed to exploit the temperature-dependent dynamics of D(2)O confined in MCM-41. Samples with three pore sizes of 1.58, 2.03, and 2.34 nm and two D(2)O contents were investigated. The reorientation correlation times of confined D(2)O in variously sized pores exhibit different(More)
This work presents a simple design for a mobile single-sided nuclear magnetic resonance (NMR) apparatus with a relatively homogeneous static magnetic field (B(0)) distribution. In the proposed design, the B(0) magnetic field of the apparatus is synthesized using only two permanent magnet blocks, i.e., a cube (main) magnet and a small shim magnet placed(More)
In this study 2H T2rho DQF NMR spectra of water in MCM-41 were measured. The T2rho double-quantum filtered (DQF) NMR signal is generated by applying a radio frequency (RF) field for various durations and then observed after a monitor RF pulse. It was found that the transfer between different quantum coherences by the couplings during long-duration RF fields(More)