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DNA Microarray Reveals That High Proportions of Human Blastocysts from Women of Advanced Maternal Age Are Aneuploid and Mosaic1
ABSTRACT Trophectoderm (TE) biopsy and DNA microarray have become the new technologies for preimplantation genetic diagnosis in humans. In this study, we comprehensively examined aneuploid formation… Expand
Application of next-generation sequencing for 24-chromosome aneuploidy screening of human preimplantation embryos
BackgroundAneuploidy is a leading cause of repeat implantation failure and recurrent miscarriages. Preimplantation genetic screening (PGS) enables the assessment of the numeral and structural… Expand
Proof of concept: preimplantation genetic screening without embryo biopsy through analysis of cell-free DNA in spent embryo culture media.
OBJECTIVE To assess whether preimplantation genetic screening (PGS) is possible by testing for free embryonic DNA in spent IVF media from embryos undergoing trophectoderm biopsy. DESIGN Prospective… Expand
Identification of Chromosomal Errors in Human Preimplantation Embryos with Oligonucleotide DNA Microarray
A previous study comparing the performance of different platforms for DNA microarray found that the oligonucleotide (oligo) microarray platform containing 385K isothermal probes had the best… Expand
Imprinted NanoVelcro Microchips for Isolation and Characterization of Circulating Fetal Trophoblasts: Toward Noninvasive Prenatal Diagnostics.
Circulating fetal nucleated cells (CFNCs) in maternal blood offer an ideal source of fetal genomic DNA for noninvasive prenatal diagnostics (NIPD). We developed a class of nanoVelcro microchips to… Expand
Aberrant seed development in Litchi chinensis is associated with the impaired expression of cell wall invertase genes
- Jie-qiong Zhang, Zichen Wu, +4 authors Huicong Wang
- Biology, Medicine
- Horticulture Research
- 1 August 2018
Cell wall invertase (CWIN) are known to play important roles in seed development. However, most reports to date have focused on a single gene family member, and have mainly investigated CWIN… Expand
Transfer of embryos with segmental mosaicism is associated with a significant reduction in live-birth rate.
OBJECTIVE To evaluate the impact of segmental mosaicism on pregnancy outcomes from the transfer of embryos previously designated as euploid. DESIGN Retrospective cohort analysis. SETTING Single,… Expand
Earlier day of blastocyst development is predictive of embryonic euploidy across all ages: essential data for physician decision-making and counseling patients
- A. Kaing, L. Kroener, +5 authors M. Shamonki
- Biology, Medicine
- Journal of Assisted Reproduction and Genetics
PurposeThe purpose of this study is to evaluate whether day of blastocyst development is associated with embryo chromosomal status as determined by high-density oligonucleotide microarray comparative… Expand
The Prevalence of Chromosomal Deletions Relating to Developmental Delay and/or Intellectual Disability in Human Euploid Blastocysts
Chromosomal anomalies in human embryos produced by in vitro fertilization are very common, which include numerical (aneuploidy) and structural (deletion, duplication or others) anomalies. Our… Expand
A novel antimicrobial substance produced by Lactobacillus rhamnous LS8
Abstract Superbugs or multi-drug resistant pathogens are not only clinical issue but also highlighted in food safety. However, development of new antibiotics and safe preservatives is declining. A… Expand