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Contribution of TRPV1 and multidrug resistance proteins in the permeation of capsaicin across different intestinal regions.
It is proved that the permeability of capsaicin across colon was significantly higher than that across jejunum or ileum, and the role of transient receptor potential cation channel (TRPV1) might mediate the transport of capsicin across the intestinal membrane. Expand
Grape Seed Procyanidin Reversal of P-glycoprotein Associated Multi-Drug Resistance via Down-regulation of NF-κB and MAPK/ERK Mediated YB-1 Activity in A2780/T Cells
GSP reverses P-glycoprotein associated MDR by inhibiting the function and expression of P-gp through down-regulation of NF-κB activity and MAPK/ERK pathway mediated YB-1 nuclear translocation, offering insight into the mechanism of reversing M DR by natural polyphenol supplement compounds. Expand
Metabolomics approach based on ultra-high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry to identify the chemical constituents of the Traditional Chinese
A basic chemical profile for the quality control and further mechanism research of Er-Zhi-Pill is provided and 16 components, including salidroside, specneuzhenide and wedelolactone, contributed most to the observed differences. Expand
Permeabilities of rebamipide via rat intestinal membranes and its colon specific delivery using chitosan capsule as a carrier.
There was a regional difference in the permeability of Rabamipide across the jejunum, ileum and the colon, and passive diffusion seems to be one of the major transport mechanisms of rebamipid. Expand
[Analysis of capsaicin in rat plasma using liquid chromatography-tandem mass spectrometry].
The LC-MS/MS system is simple, accurate, reliable and time-saving for determination of trace amount of capsaicin in plasma. Expand
Metabolomics approach based on UHPLC – Q-TOF-MS to identify the chemical constituents of the Traditional Chinese Er-Zhi-Pill
Er-Zhi-Pill, which consists of Ligustri lucidi fructus and Ecliptae prostratae herba, is a classical traditional Chinese medicinal formulation widely used as a liver-nourishing and kidney-enrichingExpand
Utility of in vitro and in vivo systems for studying the permeability of capsaicin and nonivamide through different intestinal regions
It is demonstrated that capsaicin and nonivamide exhibit varying permeabilities across several different intestinal tissues and the relevance of such extended investigations to healthcare is underscored by the lower cost ofNonivamide versus Capsaicin, along with potential application in prevention and management of the disease. Expand
Preparation of the polyclonal antibody of human papillomavirus type HPV33 for E6E7
The recombinant proteins and antibodies may be used in the clinical detection and pathogenesis research of HPV33 type human papilloma disease. Expand
[Effect of capsaicin on intestinal permeation of P-glycoprotein substrate rhodamine 123 and fluorescein sodium in rats].
Capsaicin can affect the transport of R123 and CF across rat jejunal membranes, and this effect is shows an obvious intestine segment-related difference probably because of the different distribution of P-gp or tight junction in the intestines. Expand