Liam James McGuffin

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The PSIPRED protein structure prediction server

Liam James McGuffin, Kevin Bryson, David T. Jones
Bioinformatics
2000

SUMMARY The PSIPRED protein structure prediction server allows users to submit a protein sequence, perform a prediction of their choice and receive the results of the prediction both textually via… (More)

Prediction and functional analysis of native disorder in proteins from the three kingdoms of life.

Jonathan J. Ward, Jaspreet Singh Sodhi, Liam James McGuffin, Brian F. Buxton, David T. Jones
Journal of molecular biology
2004

An automatic method for recognizing natively disordered regions from amino acid sequence is described and benchmarked against predictors that were assessed at the latest critical assessment of… (More)

Protein structure prediction servers at University College London

Kevin Bryson, Liam James McGuffin, Russell L. Marsden, Jonathan J. Ward, Jaspreet Singh Sodhi, David T. Jones
Nucleic Acids Research
2005

A number of state-of-the-art protein structure prediction servers have been developed by researchers working in the Bioinformatics Unit at University College London. The popular PSIPRED server allows… (More)

The DISOPRED server for the prediction of protein disorder

Jonathan J. Ward, Liam James McGuffin, Kevin Bryson, Bernard F. Buxton, David T. Jones
Bioinformatics
2004

UNLABELLED Dynamically disordered regions appear to be relatively abundant in eukaryotic proteomes. The DISOPRED server allows users to submit a protein sequence, and returns a probability estimate… (More)

Improvement of the GenTHREADER Method for Genomic Fold Recognition

Liam James McGuffin, David T. Jones
Bioinformatics
2003

MOTIVATION In order to enhance genome annotation, the fully automatic fold recognition method GenTHREADER has been improved and benchmarked. The previous version of GenTHREADER consisted of a simple… (More)

Secondary structure prediction with support vector machines

Jonathan J. Ward, Liam James McGuffin, Bernard F. Buxton, David T. Jones
Bioinformatics
2003

MOTIVATION A new method that uses support vector machines (SVMs) to predict protein secondary structure is described and evaluated. The study is designed to develop a reliable prediction method using… (More)

Rapid model quality assessment for protein structure predictions using the comparison of multiple models without structural alignments

MOTIVATION The accurate prediction of the quality of 3D models is a key component of successful protein tertiary structure prediction methods. Currently, clustering- or consensus-based Model Quality… (More)

Intrinsic disorder prediction from the analysis of multiple protein fold recognition models

Liam James McGuffin
Bioinformatics
2008

MOTIVATION Intrinsic protein disorder is functionally implicated in numerous biological roles and is, therefore, ubiquitous in proteins from all three kingdoms of life. Determining the disordered… (More)

Benchmarking secondary structure prediction for fold recognition.

If secondary structure predictions are to be incorporated into fold recognition methods, an assessment of the effect of specific types of errors in predicted secondary structures on the sensitivity… (More)

Rapid protein domain assignment from amino acid sequence using predicted secondary structure.

Russell L. Marsden, Liam James McGuffin, David T. Jones
Protein science : a publication of the Protein…
2002

The elucidation of the domain content of a given protein sequence in the absence of determined structure or significant sequence homology to known domains is an important problem in structural… (More)

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