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OBJECTIVE Gaucher disease is caused by mutations in the glucocerebrosidase 1 gene that result in deficiency of the lysosomal enzyme glucocerebrosidase. Both homozygous and heterozygous glucocerebrosidase 1 mutations confer an increased risk for developing Parkinson disease. Current estimates indicate that 10 to 25% of Parkinson patients carry(More)
OBJECTIVES Open heart surgery is associated with a massive systemic inflammatory response. Neutrophils, are the main mediator of this response. We hypothesised that the degree of neutrophil activation and inflammatory response to open heart surgery varies individually and correlates with clinical outcome. The aim of this study was to determine if individual(More)
  • L Daly
  • Australian nursing journal
  • 1999
To manage pain effectively, clinicians need to have an understanding of the processes involved in the facilitation of pain transmission from the site of injury to the CNS and processes that augment or inhibit that transmission. Significant advances in our under-standing of the complex and integrated communication system involved in pain transmission have(More)
We present a framework for comprehensive model-based systematic design and staged verification of Human-in-the-Loop Cyber-Physical Systems (HiLCPS) to handle their inherent complexity. HiLCPS are systems where humans are in the middle of the feedback loop between their cyber and the physical components. HiLCPS designers require modern tools and simpler(More)
  • L Daly
  • Australian nursing journal
  • 1999
Regardless of their area of clinical practice, nurses are faced on a daily basis with the challenge of effectively managing their patient's pain. Despite significant technological advances, inadequate treatment of pain is still widely reported in the literature.
  • L Daly
  • Australian nursing journal
  • 1997
Guidelines for the handling of cytotoxic drugs and related waste in health care establishments have recently been developed by the WorkCover Authority of NSW in collaboration with the New South Wales College of Nursing. Competencies for accreditation of staff involved in the reconstitution, storage, transport, administration and management of waste related(More)
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