Liam Daly

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OBJECTIVES Open heart surgery is associated with a massive systemic inflammatory response. Neutrophils, are the main mediator of this response. We hypothesised that the degree of neutrophil activation and inflammatory response to open heart surgery varies individually and correlates with clinical outcome. The aim of this study was to determine if individual(More)
OBJECTIVE Gaucher disease is caused by mutations in the glucocerebrosidase 1 gene that result in deficiency of the lysosomal enzyme glucocerebrosidase. Both homozygous and heterozygous glucocerebrosidase 1 mutations confer an increased risk for developing Parkinson disease. Current estimates indicate that 10 to 25% of Parkinson patients carry(More)
We present a framework for comprehensive model-based systematic design and staged verification of Human-in-the-Loop Cyber-Physical Systems (HiLCPS) to handle their inherent complexity. HiLCPS are systems where humans are in the middle of the feedback loop between their cyber and the physical components. HiLCPS designers require modern tools and simpler(More)
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