Liam Chen

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Tauopathies are a group of neurodegenerative disorders that include hereditary frontotemporal dementias (FTDs) such as FTD with parkinsonism linked to chromosome 17 (FTDP-17), as well as sporadic variants of FTDs like progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick's disease. These diverse diseases all have in common the(More)
CRISPR/Cas9 Overview CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats) and the CRISPR-associated (Cas) proteins are essential parts of adaptive immune system in bacteria and archaea against invading viruses and plasmids [1-3]. Three types of CRISPR systems exist, of which type II is the simplest one, only requires one Cas protein, Cas9(More)
BACKGROUND We describe the brain magnetic resonance imaging (MRI) abnormalities and neuropathologic findings of patients with Sturge-Weber syndrome and medically refractory epilepsy. METHODS We reviewed the clinical features, preoperative MRI studies, and pathologic findings of all patients with Sturge-Weber syndrome who underwent excisional surgery for(More)
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