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A Decrease in Anandamide Signaling Contributes to the Maintenance of Cutaneous Mechanical Hyperalgesia in a Model of Bone Cancer Pain
Tumors in bone are associated with pain in humans. Data generated in a murine model of bone cancer pain suggest that a disturbance of local endocannabinoid signaling contributes to the pain. WhenExpand
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Neurotrophin activation of NFAT‐dependent transcription contributes to the regulation of pro‐nociceptive genes
Nerve growth factor (NGF) and brain‐derived neurotrophic factor (BDNF) play key roles in the development of inflammation‐induced hyperalgesia by triggering the expression of pro‐nociceptive genesExpand
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Peroxisome Proliferator-Activated Receptor α Mediates Acute Effects of Palmitoylethanolamide on Sensory Neurons
The amplitude of the depolarization-evoked Ca2+ transient is larger in dorsal root ganglion (DRG) neurons from tumor-bearing mice compared with that of neurons from naive mice, and the change isExpand
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Chemical Interactions between Fibrosarcoma Cancer Cells and Sensory Neurons Contribute to Cancer Pain
In an experimental model of cancer pain, the hyperalgesia that occurs with osteolytic tumor growth is associated with the sensitization of nociceptors. We examined functional and molecular changes inExpand
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Substance P initiates NFAT‐dependent gene expression in spinal neurons
Persistent hyperalgesia is associated with increased expression of proteins that contribute to enhanced excitability of spinal neurons, however, little is known about how expression of these proteinsExpand
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JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy.
Cisplatin has been used effectively to treat a variety of cancers but its use is limited by the development of painful peripheral neuropathy. Because the endocannabinoid 2-arachidonoyl-sn-glycerolExpand
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PPAR α mediates acute effects of palmitoylethanolamide on sensory neurons
The amplitude of the depolarization-evoked Ca2+ transient is larger in dorsal root ganglion (DRG) neurons from tumor-bearing mice compared to that of neurons from naive mice, and the change isExpand
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