Lia Donahue

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The purpose of this study was to determine whether schizophrenia was associated with alterations in alcohol response that might explain the elevated risk for AUDs in this population. In a randomized, double-blind, placebo-controlled, counter-balanced 3 test day laboratory study, the effects of alcohol were compared in 23 subjects with schizophrenia (without(More)
Expression of the rat (RH-I/SkM2) and human (hH1/SCN5A) tetrodotoxin-resistant (TTX-R), voltage-sensitive sodium channels is thought to be specific to cardiac tissue. We detected RH-I/SkM2 mRNA in newborn rat brain using both RNase protection assay analysis and in situ hybridization and in adult rat brain using RNase protection assay analysis. This(More)
Tetrodotoxin-insensitive (TTX-I) sodium currents have been recorded from newborn and adult rat sensory neurons, but the sodium channel gene(s) responsible for the TTX-I current are unknown. Because SkM2, one of six voltage-sensitive sodium channel genes cloned from rat, encodes the only cloned channel that is relatively resistant to tetrodotoxin, we sought(More)
RT4 is a family of cell lines derived from a rat peripheral neurotumor and consists of a multipotential stem cell line that spontaneously gives rise to three derivative cell types: one glial-like and two neuronal-like. Previous studies have established that the RT4 glial derivative expresses many properties of Schwann cells; however, the neuronal(More)
RT4 is a family of cell lines derived from a rat peripheral neurotumor and consists of a multipotential stem cell which spontaneously gives rise to a glial derivative and two neuronal derivatives. To begin to understand the role(s) of transcription factors in neural differentiation, we examined the expression of ten transcription factor genes (MASH1,(More)
BACKGROUND This study tested the hypothesis that deficits in gamma-aminobutyric acid type A (GABA(A)) receptor function might create a vulnerability to the psychotogenic and perceptual altering effects of serotonergic (5-HT(2A/2C)) receptor stimulation. The interactive effects of iomazenil, an antagonist and partial inverse agonist of the benzodiazepine(More)
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