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Belgian endive (Cichorium intybus) was genetically transformed usingAgrobacterium rhizogenes to insert wild type root-inducing, leftward, transferred DNA (Ri TL-DNA) into the nuclear genome. Transformed root cultures gave rise to plants (R0 generation) having the transformed phenotype described for other species, including increased branching, sterility,(More)
Vascular smooth muscle (VSM) expresses calcium/calmodulin-dependent protein kinase II (CaMKII)-δ and -γ isoforms. CaMKIIδ promotes VSM proliferation and vascular remodeling. We tested CaMKIIγ function in vascular remodeling after injury. CaMKIIγ protein decreased 90% 14 d after balloon injury in rat carotid artery. Intraluminal transduction of adenovirus(More)
Migration and adhesion of tumor cells are essential prerequisites for the formation of metastases in malignant diseases. Chemokine receptor 7 (CCR7) has been shown to regulate integrin which can then facilitate adhesion of cancer cells to and/or migration through the extracellular matrix (ECM). In order to identify the connection between CCR7 and beta1(More)
Airway smooth muscle (ASM) is a key target cell in allergen-induced asthma known to contribute to airway hyperresponsiveness (AHR) and chronic airway remodeling. Changes in ASM calcium homeostasis have been shown to contribute to AHR although the mechanisms and Ca2+ signal effectors are incompletely understood. In the present study, we tested the function(More)
One transcription factor mediator of Ca(2+)-signals is cAMP response element-binding protein (CREB). CREB expression and/or activity negatively correlates with vascular smooth muscle (VSM) cell proliferation and migration. Multifunctional Ca(2+)/calmodulin-dependent protein kinases, including CaMKII, have been demonstrated to regulate CREB activity through(More)
The multifunctional Ca(2+)/calmodulin-dependent protein kinase II δ-isoform (CaMKIIδ) promotes vascular smooth muscle (VSM) proliferation, migration, and injury-induced vascular wall neointima formation. The objective of this study was to test if microRNA-30 (miR-30) family members are endogenous regulators of CaMKIIδ expression following vascular injury(More)
When the crypto-period is expired or the key is compromised, trusted third party (TTP) broadcasts the materials of key update. The method cannot guarantee that all the nodes access to key materials in time if nodes work on different spectrums in cognitive radio networks. This paper presents a new algorithm based on the logistic model (KULCR) which reduces(More)
OBJECTIVE To investigate the chemical constituents of the lichen plants Parmelia tinctorum and Parmelia nimandairana collected from Meng Mountain in Shandong province. METHODS Various chromatographic techniques were used to isolate and purify the constituents and their structures were elucidated by means of spectral evidence and physiochemical properties.(More)
OBJECTIVE Laminar flow activates myocyte enhancer factor 2 (MEF2) transcription factors in vitro to induce expression of atheroprotective genes in the endothelium. Here we sought to establish the role of Mef2c in the vascular endothelium in vivo. APPROACH AND RESULTS To study endothelial Mef2c, we generated endothelial-specific deletion of Mef2c using(More)
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