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AIM Quercetin affects the expressions of leptin and its receptor in human gastric cancer MGC-803 cells and JAK-STAT pathway. METHODS The cultured MGC-803 cells were divided into three groups: CONTROL GROUP the cultured cells without quercetin, and Quercetin group: the cultured cells with quercetin(40 μmol/L), and AG490group: the cultured cells(More)
AIM To study the effect of quercetin on the growth and apoptosis of human gastric carcinoma cell line MGC-803. METHODS The measurement of inhibitory rate and apoptotic index(AI) of quercetin were done by MTT assay and TUNEL assay. The positive expression rate of P53, C-myc and P16 were detected by immunocytochemical staining. RESULTS Quercetin at(More)
Macrophage-derived foam cells are well known for their key role in development of atherosclerosis (AS). The present study aimed to examine whether dioscin exerts anti-atherosclerotic activity and inhibits foam cell formation. A high-fat induced AS model and ox-LDL treated macrophages were established and received treatment of dioscin. Anti-atherosclerotic(More)
Severe hand-foot-and-mouth disease (HFMD) caused by Enterovirus 71 (EV71) always accompanies with inflammation and neuronal damage in the central nervous system (CNS). During neuronal injuries, cell surface-exposed calreticulin (Ecto-CRT) is an important mediator for primary phagocytosis of viable neurons by microglia. Our data confirmed that brainstem(More)
Hemophilia A (Hemophilia A, HA) is an X-linked recessive hereditary coagulation function disorder, the deficiency and dysfunction of blood coagulation were caused by the mutations of gene encoding clotting factor VIII. The treatment of hemophilia A still depends on the replacement therapy with blood coagulation factor. However, the repeated infusion of(More)
The aim of study was to investigate the relationship between polymorphisms of FCGR2B232 1/T oligonucleotide and the susceptibility of children with idiopathic thrombocytopenic purpura (ITP). DNA from 76 patients with ITP and 37 controls was extracted. The SNPs of FCGR2B-232 was detected by polymerase chain reaction (PCR) combined with direct sequencing. The(More)
AIM To investigate the mechanism of quercetin on the inhibition of the lymphatic metastasis in human gastric cancer cells MGC-803. METHODS Cells were divided into the control group and the quercetin (Que)-treated group. Immunohistochemistry and RT-PCR were used to detect the expression of vascular endothelial growth factor C (VEGF-C) and VEGFR-3 of human(More)
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