Production of soluble and functional engineered antibodies in Escherichia coli improved by FkpA.
It is reported that fusion or co-expression of FkpA, the E. coli periplasmic peptidyl-prolyl-isomerase with chaperone activity, substantially improves soluble and functional expression of scAbs.
A new model of trispecific antibody resulting the cytotoxicity directed against tumor cells.
- Li-ping Song, Julong Cheng, Hua-liang Huang
- Biology, MedicineSheng wu hua xue yu sheng wu wu li xue bao Acta…
- 1 June 2003
It was demonstrated that this new type of recombinant scFv antibody set up a new technological platform for T cells based immunotherapy against cancer, especially with the failure on MHC antigen presentation or absence of costimulating signal.
A New Format of Single Chain Tri-specific Antibody with Diminished Molecular Size Efficiently Induces Ovarian Tumor Cell Killing
A new format of single chain tri-specific antibody, TR3H, whose molecular size is smaller than sTRI is generated, which possesses properties that support its potential as a new tumor immunotherapeutic agent.
Anticorps trispecifique monocatenaire cyclique
L'invention porte sur un anticorps antitumoral trispecifique monocatenaire cyclique qui est combine a un anticorps monocatenaire, Fab, antitumoral et a CD3 ou CD28 Fab anti-humain modifie. Cette…