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Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder
TLDR
The present study aims to examine the effect of flavonoids in alleviating the enhanced anxiety and fear response induced in two PTSD animal models and assess the changes of brain monoaminergic neurotransmitters after chronic flavonoid administration.
Anxiolytic-like effects of YL-IPA08, a potent ligand for the translocator protein (18 kDa) in animal models of post-traumatic stress disorder.
TLDR
The findings from the current study showed that YL-IPA08, a potent and selective TSPO ligand, had a clear anti-PTSD-like effect, which might be partially mediated by binding to T SPO and the subsequent synthesis of allopregnanolone.
Deferoxamine attenuates lipopolysaccharide-induced neuroinflammation and memory impairment in mice
TLDR
The results suggest that DFO may possess a neuroprotective effect against LPS-induced neuroinflammation and cognitive deficits via mechanisms involving maintenance of less brain iron, prevention of neuro inflammation, and alleviation of oxidative stress and apoptosis.
Anxiolytic effects of ketamine in animal models of posttraumatic stress disorder
TLDR
The results suggest that ketamine exerts a therapeutic effect on PTSD that might be at least partially mediated by an influence on BDNF signaling in the hippocampus.
Involvement of allopregnanolone in the anti-PTSD-like effects of AC-5216
TLDR
It is demonstrated that AC-5216 has a clear anti-PTSD-like effect, which might be partially mediated by binding to TSPO and the subsequent synthesis of allopregnanolone.
The 18 kDa Translocator Protein (TSPO) Overexpression in Hippocampal Dentate Gyrus Elicits Anxiolytic-Like Effects in a Mouse Model of Post-traumatic Stress Disorder
TLDR
The hypothesis that the overexpression of TSPO in hippocampus dentate gyrus (DG) could alleviate the anxiogenic-like response in the mice model of PTSD induced by foot-shock is tested and the anti-PTSD-like effect of hippocampal T SPO over-expression could be at least partially mediated by up-regulation of Allo and subsequent stimulation of the adult hippocampal neurogenesis.
[Neonatal fluoxetine exposure induced depression-like behaviors in adult Kunming mice and the antidepressant-like effect of agmatine].
TLDR
It is indicated that neonatal exposure to fluoxetine induces depressive-like behaviors in the adult mice, and agmatine reverses these behaviors, which may be closely related to the enhancement of the hippocampal AC activity.
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