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Identification of influenza A nucleoprotein as an antiviral target
TLDR
Nucleozin impeded influenza A virus replication in vitro with a nanomolar median effective concentration (EC50) and protected mice challenged with lethal doses of avian influenza A H5N1 and demonstrated that viral NP is a valid target for the development of small-molecule therapies. Expand
Study of the mechanical, thermal properties and flame retardancy of rigid polyurethane foams prepared from modified castor-oil-based polyols
Po1lyurethane foams (PUFs) were prepared using modified castor-oil-based polyols (MCOs). In the first stage, castor oil (CO) was converted into monoglycerides and diglycerides by alcoholysis withExpand
Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori
TLDR
A new aroE gene encoding SDH from Helicobacter’s strain SS1 is identified and expected to favor better understanding the features of SDH and provide useful information for the development of novel antibiotics to treat H.’pylori‐associated infection. Expand
Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both β-Amyloid Production and Clearance
TLDR
It is reported that the natural product arctigenin from Arctium lappa (L.) can both inhibit Aβ production by suppressing β-site amyloid precursor protein cleavage enzyme 1 expression and promote Aβ clearance by enhancing autophagy through AKT/mTOR signaling inhibition and AMPK/Raptor pathway activation. Expand
METHODS TO IMPROVE LIGNIN’S REACTIVITY AS A PHENOL SUBSTITUTE AND AS REPLACEMENT FOR OTHER PHENOLIC COMPOUNDS: A BRIEF REVIEW
Lignin is readily available as a by-product from the pulp and paper industry. It is considered to be a promising substitute for phenol in phenol-formaldehyde (PF) resin synthesis, given theExpand
Activation of Protein Serine/Threonine Phosphatase PP2Cα Efficiently Prevents Liver Fibrosis
TLDR
The findings suggested that PP2Cα activation might be an attractive new strategy for treating liver fibrosis while the small molecular activator NPLC0393 might represent a lead compound for antifibrogenic drug development. Expand
Identification of Novel Small-Molecule Inhibitors of Severe Acute Respiratory Syndrome-Associated Coronavirus by Chemical Genetics
TLDR
Three selected compounds validated to be inhibitors of SARS-CoV Mpro, Hel, and viral entry, respectively, exhibited potent antiviral activity (EC50 < 10 μM) and comparable inhibitory activities in target-specific in vitro assays. Expand
The study of mechanical behavior and flame retardancy of castor oil phosphate-based rigid polyurethane foam composites containing expanded graphite and triethyl phosphate
Abstract The goal of this work was the synthesis of novel flame-retarded polyurethane rigid foam with a high percentage of castor oil phosphate flame-retarded polyol (COFPL) derived from renewableExpand
Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers.
TLDR
The potencies of taccalonolides AF and AJ and their direct interaction with tubulin, together with the previous excellent in vivo antitumor activity of this class, reveal the potential of the tacconolides as new anticancer agents. Expand
Chemical Groups and Structural Characterization of Lignin via Thiol-Mediated Demethylation
Abstract A new approach to increase the reactivity of lignin by thiol-mediated demethylation was investigated in this study. Demethylated lignin was characterized by the changes in its hydroxyl andExpand
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