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  • Cynthia M Beall, Gianpiero L. Cavalleri, +26 authors Yong Tang Zheng
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2010 (First Publication: 7 June 2010)
  • By impairing both function and survival, the severe reduction in oxygen availability associated with high-altitude environments is likely to act as an agent of natural selection. We used genomic andContinue Reading
  • Eva Andrés-Mateos, C. Perier, +9 authors Valina L. Dawson
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2007 (First Publication: 11 September 2007)
  • Parkinson's disease (PD) is a common neurodegenerative movement disorder. Whereas the majority of PD cases are sporadic, rare genetic defects have been linked to this prevalent movement disorder.Continue Reading
  • Nahyun Choi, Boyu Zhang, Li Zhang, Michael Ittmann, Li Min Xin
  • Biology, Medicine
  • Cancer cell
  • 2012 (First Publication: 1 February 2012)
  • The prostate epithelial lineage hierarchy and the cellular origin for prostate cancer remain inadequately defined. Using a lineage-tracing approach, we show that adult rodent prostate basal andContinue Reading
  • Julie R. McMullen, Tetsuo Shioi, +4 authors Seigo Izumo
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2003 (First Publication: 24 September 2003)
  • An unresolved question in cardiac biology is whether distinct signaling pathways are responsible for the development of pathological and physiological cardiac hypertrophy in the adult. PhysiologicalContinue Reading
  • Da-Li Zheng, Li Zhang, +7 authors Ze-Guang Han
  • Biology, Medicine
  • Journal of hepatology
  • 2009 (First Publication: 1 February 2009)
  • BACKGROUND/AIMS The hepatitis B virus X protein (HBx) has been implicated as a potential trigger of the epigenetic deregulation of some genes, but the underlying mechanisms remain unknown. The aim ofContinue Reading
  • Joanne Marie Lewohl, Li-hui Wang, Michael F. Miles, Li Zhang, Peter R. Dodd, Robert A Harris
  • Biology, Medicine
  • Alcoholism, clinical and experimental research
  • 2000 (First Publication: 1 December 2000)
  • BACKGROUND Changes in brain gene expression are thought to be responsible for the tolerance, dependence, and neurotoxicity produced by chronic alcohol abuse, but there has been no large scale studyContinue Reading
  • Bryan N. Brown, Ricardo Borrero Londoño, +6 authors Stephen F. Badylak
  • Biology, Medicine
  • Acta biomaterialia
  • 2012 (First Publication: 1 March 2012)
  • Macrophages have been classified as having plastic phenotypes which exist along a spectrum between M1 (classically activated; pro-inflammatory) and M2 (alternatively activated; regulatory,Continue Reading
  • Jingrong Peng, Li Zhang, L Drysdale, Guo hua Fong
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2000 (First Publication: 18 July 2000)
  • We have studied the role of the basic helix-loop-helix-PAS transcription factor EPAS-1/hypoxia-inducible factor 2alpha in vascular development by gene targeting. In ICR/129 Sv outbred background,Continue Reading