Li Yubao

Learn More
A ZnO containing nano-hydroxyapatite/chitosan (n-HA/CS) cement was developed and its bone formation ability was investigated in vitro and in vivo. The physico-chemical properties of the cement were determined in terms of pH variation during and after setting, injectability and wettability. The results indicated that, the pH varied from 7.04 to 7.12(More)
For tissue engineered bone constructs, calcium phosphate cement (CPC) has a high potential as scaffold material because of its biocompatibility and osteoconductivity. However, in vivo resorption and tissue ingrowth is slow. To address these issues, microspheres can be incorporated into the cement, which will create macroporosity after in situ degradation.(More)
Chitosan/nano-hydroxyapatite composites with different weight ratios were prepared through a co-precipitation method using Ca(OH)(2), H(3)PO(4) and chitosan as starting materials. The properties of these composites were characterized by means of TEM, IR, XRD, burn-out test and universal matertial test machine. Additionally, in vitro tests were also(More)
An artificial cornea consisted of a porous nano-hydroxyapatite/poly (vinyl alcohol) hydrogel (n-HA/PVA-H) skirt and a transparent center poly (vinyl alcohol) hydrogel (PVA-H) were prepared. The n-HA/PVA-H skirt was homogeneously porous and these pores were interconnected. Inter-penetrating network was observed along the interface between the core and the(More)
The in vivo behavior of infrared-heated, RF magnetron-sputtered hydroxylapatite (HA) and calcium pyrophosphate (DCPP) coated titanium discs was investigated. The discs were implanted subcutaneously in the back of six goats for 2, 4, 8 and 12 weeks. At the end of the study, coated discs were removed and examined on their physicochemical properties by X-ray(More)
In this study, we report the physico-chemical and biological properties of a novel biodegradable composite scaffold made of nano-hydroxyapatite and natural derived polymers of chitosan and carboxymethyl cellulose, namely, n-HA/CS/CMC, which was prepared by freeze-drying method. The physico-chemical properties of n-HA/CS/CMC scaffold were tested by infrared(More)
Phosphoric acid solution was used to react with commercial hydroxyapatite (HA) powders to demonstrate the possibility of converting HA to non-stoichiometric apatite and thus to treat porous HA ceramics, to form a thin bone-apatite like layer on the HA ceramic surface. Such a carbonate-containing non-stoichiometric apatite "bioceramic" would be more(More)
Apatitic calcium phosphate cements (CPCs) have been widely used as bone grafts due to their excellent osteoconductive properties, but the degradation properties are insufficient to stimulate bone healing in large bone defects. A novel approach to overcome the lack of degradability of apatitic CPC involves the development of biphasic CPCs (BCPC) based on(More)
Bioactive biomaterials can form a bone-like apatite layer on their surfaces in the body, which is critical to establishing bone bonding between bioactive materials and living tissue. At present study, the bone-like apatite formation in vitro and vivo on the surface of the nano apatite/polyamide composite was studied, and the bioactive composites implanted(More)
Ca-P coatings with different Ca/P ratio and composition were successfully prepared by RF magnetron sputtering deposition. The Ca/P ratio, phase composition, structure and morphological properties were characterized by XRD, FTIR, EDS and SEM analyses. All the as-sputtered coatings were amorphous and after IR-irradiation the coatings altered into a(More)