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We examined the sera of six patients before and after i.v. infusions of autologous chronic lymphocytic leukemia (CLL) cells transduced ex vivo with an adenovirus encoding CD154 (Ad-CD154). Five patients made high-titer antibodies against adenovirus and three made IgG reactive with a leukemia-associated surface antigen, which we identified as ROR1. Anti-ROR1(More)
Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is expressed during embryogenesis and by certain leukemias, but not by normal adult tissues. Here we show that the neoplastic cells of many human breast cancers express the ROR1 protein and high-level expression of ROR1 in breast adenocarcinoma was associated with aggressive disease. Silencing(More)
This paper examines the rapid growth of China in the field of nanotechnology and the rise of collaboration between China and the US in this emerging domain. Chinese scientific papers in nanotechnology are analyzed to indicate overall trends, leading fields and the most prolific institutions. Patterns of China–US nanotechnology paper co-authorship are(More)
Authorship identity has long been an Achilles’ heel in bibliometric analyses at the individual level. This problem appears in studies of scientists’ productivity, inventor mobility and scientific collaboration. Using the concepts of cognitive maps from psychology and approximate structural equivalence from network analysis, we develop a novel algorithm for(More)
The TCP incast problem attracts a lot of attention due to its wide existence in cloud services and catastrophic performance degradation. Some effort has been made to solve it. However, the industry is still struggling with it, such as Facebook. Based on the investigation that the TCP incast problem is mainly caused by the TimeOuts (TOs) occurring at the(More)
American women of African ancestry (AA) are more likely than European Americans (EA) to have estrogen receptor (ER)-negative breast cancer. 25-hydroxyvitamin D (25OHD) is low in AAs, and was associated with ER-negative tumors in EAs. We hypothesized that racial differences in 25OHD levels, as well as in inherited genetic variations, may contribute, in part,(More)
Cell-penetrating peptides (CPPs), such as the HIV TAT peptide, are able to translocate across cellular membranes efficiently. A number of mechanisms, from direct entry to various endocytotic mechanisms (both receptor independent and receptor dependent), have been observed but how these specific amino acid sequences accomplish these effects is unknown. We(More)
In an era of energy crisis, biomass-based bioenergy research has attracted the attention of R&D managers and policy makers around the world. This study explores the structural and dynamic patterns of biomass-based bioenergy research. We measure the profile of biomass research on both macro scales (nations) and meso level (institutions) in an international(More)
PURPOSE We examined changes of the central nervous system in patients with advanced primary open-angle glaucoma (POAG). METHODS The clinical observational study included 15 patients with bilateral advanced POAG and 15 healthy normal control subjects, matched for age and sex with the study group. Retinal nerve fiber layer (RNFL) thickness was measured by(More)
We transduced chronic lymphocytic leukemia (CLL) cells lacking ZAP-70 with vectors encoding ZAP-70 or various mutant forms of ZAP-70 and monitored the response of transduced CLL cells to treatment with F(ab)(2) anti-IgM (anti-mu). CLL cells made to express ZAP-70, a kinase-defective ZAP-70 (ZAP-70-KA(369)), or a ZAP-70 unable to bind c-Cbl (ZAP-YF(292))(More)