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Melatonin prevents morphine-induced hyperalgesia and tolerance in rats: role of protein kinase C and N-methyl-D-aspartate receptors
TLDR
Melatonin have potential to attenuate repetitive morphine-induced hyperalgesia and tolerance, possibly by inhibiting PKCγ and NR1 activities in the spinal cord, as well as possible involvement of protein kinase C/N-methyl-D-aspartate pathway in melatonin-mediated pathways.
A functional relationship between trigeminal astroglial activation and NR1 expression in a rat model of temporomandibular joint inflammation.
TLDR
Astroglial activation contributes to the mechanism of TMJ pain through the regulation of NR1 expression in Sp5C, and intracisternal administration of fluorocitrate for 5 days blocked the development of mechanical hyperalgesia as well as the upregulation of GFAP and NR1 in thesp5C.
Pain Prevalence and Pain Management in a Chinese Hospital
TLDR
The prevalence of pain is higher than the abnormality of the 4 traditional vital signs in a Chinese hospital, and although pain management has broadly improved, more patient education is necessary.
Exacerbated mechanical hyperalgesia in rats with genetically predisposed depressive behavior: Role of melatonin and NMDA receptors
TLDR
A reciprocal relationship between TMJ inflammation‐induced mechanical hyperalgesia and depressive behavior is demonstrated and it is suggested that the central melatoninergic system, through modulation of the NMDA receptor expression and activity, may play a role in the mechanisms of the comorbidity between pain and depression.
Midazolam exacerbates morphine tolerance and morphine-induced hyperactive behaviors in young rats with burn injury
TLDR
Results indicate that midazolam exacerbated morphine tolerance through a spinal NMDA/PKC-mediated mechanism and chelerythrine prevented the development of morphine tolerance.
Current Status of Malignant Neuropathic Pain in Chinese Patients with Cancer: Report of a Hospital‐based Investigation of Prevalence, Etiology, Assessment, and Treatment
TLDR
This study investigated the prevalence, etiology, assessment, treatment of pain in patients with cancer as well as their quality of life (QOL) and found that cancer patients with high levels of pain are at higher risk of dying from pain-related illnesses.
The Analgesic and Emotional Response to Intravenous Lidocaine Infusion in the Treatment of Postherpetic Neuralgia: A Randomized, Double-Blinded, Placebo-controlled Study
TLDR
The analgesic response of 5 mg/kg lidocaine intravenous infusion is comparable to placebo in patients with postherpetic neuralgia, but intravenous lidocane infusion significantly reduced total analgesic consumption, and improved the overall emotional and health status.
Bilateral vs. unilateral endoscopic ultrasound-guided celiac plexus neurolysis for abdominal pain management in patients with pancreatic malignancy: a systematic review and meta-analysis
TLDR
The evidence supports the conclusion that the bilateral approach significantly reduces postoperative analgesic use, and the short-term analgesic effect and general risk of bilateral EUS-CPN are comparable with those of unilateral EUS -CPN.
Pulsed radiofrequency of brachial plexus under ultrasound guidance for refractory stump pain: a case report
TLDR
A patient with persistent and refractory upper limb stump pain is described as being successfully relieved with PRF of brachial plexus under ultrasound guidance after a 6-month follow-up period, suggesting that PRF may be considered as an alternative treatment forRefractory stump-neuroma pain.
Potential advantages of an additional forearm rubber tourniquet in intravenous regional anesthesia: a randomized clinical trial
TLDR
The combination of the additional forearm and upper arm tourniquets with a smaller amount of local anesthetic achieved more rapid onset of sensory and motor block, a similar quality of anesthesia and a lower incidence of localAnesthetic toxicity compared with the conventional technique.
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