Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis.
- P. Nagareddy, A. Murphy, I. Goldberg
- Medicine, BiologyCell Metabolism
- 7 May 2013
Hepatic Overexpression of Hormone-sensitive Lipase and Adipose Triglyceride Lipase Promotes Fatty Acid Oxidation, Stimulates Direct Release of Free Fatty Acids, and Ameliorates Steatosis*
- Brendan N. Reid, G. Ables, Li-Shin Huang
- BiologyJournal of Biological Chemistry
- 9 May 2008
A direct functional role for both HSL and ATGL in hepatic lipid homeostasis is suggested and these enzymes are identified as potential therapeutic targets for ameliorating hepatic steatosis associated with insulin resistance and obesity.
The Insulin Resistance Syndrome: Impact on Lipoprotein Metabolism and Atherothrombosis
- H. Ginsberg, Li-Shin Huang
- Medicine, BiologyJournal of Cardiovascular Risk
- 1 October 2000
This review will provide a pathophysiologic basis, based on studies on humans and in tissue culture, for the dyslipidemia of insulin resistance and the effects of insulin Resistance on the coagulation and fibrinolytic pathways to allow health professionals better to evaluate and treat patients with insulin resistance.
Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study[S]
- Robin D. Clugston, Hongfeng Jiang, W. Blaner
- Biology, ChemistryJournal of Lipid Research
- 1 November 2011
The unique combination of lipidomic and gene expression analyses allows for a better mechanistic understanding of dysregulated lipid metabolism in the development of alcoholic fatty liver disease.
DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle[S]
- Li Liu, Shuiqing Yu, I. Goldberg
- Biology, ChemistryJournal of Lipid Research
- 1 April 2011
Treatment with an inhibitor specific for DGAT1 led to striking reductions in mRNA levels of genes mediating fatty acid oxidation in cardiac and skeletal muscle, and these changes were reproduced in cultured myocytes with the DG AT1 inhibitor.
Thyroid hormone reduces cholesterol via a non-LDL receptor-mediated pathway.
- I. Goldberg, Li-Shin Huang, J. Ehrenkranz
- Biology, MedicineEndocrinology
- 4 September 2012
Thyroid hormones reduce apoB lipoproteins via a non-LDLR pathway that leads to decreased liver ApoB production, suggesting that drugs that operate in a similar manner could be a new therapy for patients with genetic defects in the LDLR.
Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice.
- Ni-Huiping Son, Tae-Sik Park, I. Goldberg
- BiologyJournal of Clinical Investigation
- 2007
Transgenic mice expressing PPARgamma1 in the heart via the cardiac alpha-myosin heavy chain (alpha-MHC) promoter developed a dilated cardiomyopathy associated with increased lipid and glycogen stores, distorted architecture of the mitochondrial inner matrix, and disrupted cristae.
The constitutive lipid droplet protein PLIN2 regulates autophagy in liver
- Tsung-Huang Tsai, Elaine Chen, B. Chang
- Biology, MedicineAutophagy
- 26 May 2017
It is shown that PLIN2 overexpression protects lipid droplets against macroautophagy/autophage, whereas PLin2 deficiency enhances autophagy and depletes hepatic TG, and its downregulation stimulates TG catabolism via autophagic function.
Apoprotein B100, an Inefficiently Translocated Secretory Protein, Is Bound to the Cytosolic Chaperone, Heat Shock Protein 70 (*)
- Mingyue Zhou, Xujun Wu, Li-Shin Huang, H. Ginsberg
- BiologyJournal of Biological Chemistry
- 20 October 1995
The results suggest that domains of nascent apoB localized on the C-terminal regions of the molecule are transiently exposed to the cytosol during translation and/or translocation, and that Hsp70 functions as a molecular chaperone to maintain apiB in a translocational competent conformation until translocation is completed.
Translocation Efficiency, Susceptibility to Proteasomal Degradation, and Lipid Responsiveness of Apolipoprotein B Are Determined by the Presence of β Sheet Domains*
- Jun-shan Liang, Xujun Wu, H. Ginsberg
- BiologyJournal of Biological Chemistry
- 25 December 1998
The results clearly demonstrate that the translocation efficiency, susceptibility to proteasomal degradation, and lipid responsiveness of apoB were determined by the presence of a lipid binding β sheet domain.
...
...