Li Shan

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In this report, a partitioned time stepping algorithm for transient flow in a porous medium coupled to a free flow in embedded conduits is analyzed. The coupled flow is modeled by the fully evolutionary Stokes-Darcy problem. This method requires only solve one, uncoupled Stokes and Darcy sub-physics and sub-domain per time step. On the interface between the(More)
Common, complex, and burdensome to individuals and society alike, neck pain is estimated to affect more than 70% of the population at some point in life and between 12-34% of the population at a given time, with one study finding that 45.5% of office workers experienced neck pain in a 12-month period [1]. We plan to build a system that would give real time(More)
OBJECTIVE Claudins are found in junctional complexes mediating cell adhesion and are involved in the attachment of tight junctions to the underlying cytoskeleton. Abnormal claudin-6 expression has been observed for a variety of malignant solid tumors, but the expression of claudin-6 in non-small cell lung cancer (NSCLC) has not yet been characterized. (More)
BACKGROUND CDH1 is a protein encoded by the CDH1 gene in humans. Loss of CDH1 function contributes to cancer progression by increasing proliferation, invasion, and/or metastasis. However, the association and clinicopathological significance between CDH1 hypermethylation and gastric cancer (GC) remains unclear. In this study, we systematically reviewed the(More)
PURPOSE The effects of cathepsin L on claudin-1 expression were investigated under hyperthermic condition in a blood-brain barrier (BBB) model in vitro, in order to estimate the potential effects of hyperthermia on BBB dysfunction. MATERIALS AND METHODS Brain microvascular endothelial cells (BMECs) and astrocytes were obtained from rat brain. The BBB(More)
The objective of the present study was to evaluate the feasibility of using model drug metoprolol succinate (MS) as a pore former to modify the initial lag phase (i.e., a slow or non-release phase in the first 1–2 h) associated with the drug release from coated pellets. MS-layered cores with high drug-layering efficiency (97% w/w) were first prepared by(More)
This paper presents the stabilities for both two modular, projection-based variational multiscale (VMS) methods and the error analysis for only first one for the incompressible Naiver-Stokes equations, expanding the analysis in [39] to include nonlinear eddy viscosities. In VMS methods, the influence of the unresolved scales onto the resolved small scales(More)