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IMPORTANCE Pronounced inflammatory reactions occurring shortly after intracerebral hemorrhage (ICH) contribute to the formation and progression of perihematomal edema (PHE) and secondary brain injury. We hypothesized that modulation of brain inflammation reduces edema, thus improving clinical outcomes in patients with ICH. OBJECTIVE To investigate whether(More)
About IFC IFC, a member of the World Bank Group, is the largest global development institution focused exclusively on the private sector. We help developing countries achieve sustainable growth by financing investment, mobilizing capital in international financial markets, and providing advisory services to businesses and governments. In FY12, our(More)
An improved land–ocean global monthly precipitation anomaly reconstruction is developed for the period beginning in 1900. Reconstructions use the available historical data and statistics developed from the modern satellite-sampled period to analyze variations over the historical presatellite period. This paper documents the latest in a series of(More)
[1] The trends of global precipitation in 1900–2005 are evaluated using a historical precipitation reconstruction and coupled model simulations, Coupled Model Intercomparison Project 5 (CMIP5) and Coupled Model Intercomparison Project Phase 3. A significant increasing trend in the global oceanic precipitation is identified in both the reconstruction and(More)
Yueju, a Traditional Chinese Medicine formula, exhibited fast-onset antidepressant responses similar to ketamine. This study focused on assessing the rapid and persistent antidepressant efficacy of Yueju and ketamine in chronically stressed mice and its association with alternations in prefrontal N-methyl-D-aspartate (NMDA) receptor and mammalian target of(More)
This study investigated the effects of propofol and electroconvulsive shock (ECS), the analogue of electroconvulsive therapy (ECT) in animals, on tissue plasminogen activator (tPA) and its inhibitor (PAI-1) as well as the precursor of brain-derived neurotrophic factor (proBDNF)/mature BDNF (mBDNF) ratio in depressive rats. ECT is an effective treatment for(More)
INTRODUCTION Conventional antidepressants, including fluoxetine, have a major disadvantage in delayed onset of efficacy. Yueju, an herbal medicine used to treat mood disorders was recently found to exhibit rapid antidepressant effects. The present study was conducted to evaluate the role of Yueju in rapidly acting on major depressive disorder (MDD). (More)
Recently, microfluidic systems have shown great potential in the study of molecular and cellular biology. With its excellent properties, such as miniaturization, integration and automation, to name just a few, microfluidics creates new opportunities for the spatial and temporal control of cell growth and environmental stimuli in vitro. In the field of(More)
Although some studies have validated the 2001 World Health Organization (WHO) classification of acute myeloid leukemia (AML), including the importance of multilineage dysplasia, others have suggested that multilineage dysplasia correlates with unfavorable cytogenetics but has no independent impact on prognosis. In 2008, the revised WHO classification has(More)
OBJECTIVE The aim of this study was to investigate the possible microstructural abnormalities of the corpus callosum (CC) in adult patients with migraine without aura complicated with depressive/anxious disorder. BACKGROUND Emotional disorders, especially depression and anxiety, are with relatively higher incidence in migraine population. However, the(More)