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BACKGROUND Childhood medulloblastoma is associated with significant morbidity and mortality that is compounded by neurotoxicity for the developing brain caused by current therapies, including surgery, craniospinal radiation, and chemotherapy. Innate therapeutic resistance of some aggressive pediatric medulloblastoma has been attributed to a subpopulation of(More)
Pathophysiological hypoxia, which fosters the glioma stem-like cell (GSC) phenotype, is present in high-grade gliomas and has been linked to tumor development, invasiveness and resistance to chemotherapy and radiation. Oncolytic virotherapy with engineered herpes simplex virus-1 (HSV-1) is a promising therapy for glioblastoma; however, the efficacy of(More)
Staphylococcus aureus (S. aureus) is a bacterium frequently found proliferating on metal surfaces such as stainless steels used in healthcare and food processing facilities. Past research has shown that a novel Cu-bearing 304 type stainless steel (304CuSS) exhibits excellent antibacterial ability (i.e. against S. aureus) in a short time period (24h.). This(More)
:Tap water is one of the most commonly used water resources in our daily life, where 10 the pathogenic bacteria, such as Staphylococcus aureus and Escherichia coli may pose a potential 11 health risk to humans. Furthermore, the mutualism of different pathogenic bacteria in actual tap 12 water may diminish the antibacterial effect of antibacterial agents.(More)
BACKGROUND Hitherto, a population-based analysis of the cause of death in urban areas of Western China has not been undertaken over an extended period. The aims of this study were to calculate the overall and annual cause-specific mortality rates by age and sex in urban areas of Western China from 2003 to 2012 and to evaluate the quality of the data. (More)
Helicobacter pylori (H. pylori) infection is closely related to various gastroduodenal diseases. Virulence factors and bacterial load of H. pylori are associated with clinical outcomes, and drug-resistance severely impacts the clinical efficacy of eradication treatment. Existing detection methods are low-throughput, time-consuming and labor intensive.(More)
  • Yang Xiaoling, Zhao Li, Li ShuQiang, Ma Shengchao, Yang Anning, Ding Ning +5 others
  • 2016
Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular diseases, such as atherosclerosis. HHcy promotes atherogenesis by modifying the histone methylation patterns and miRNA regulation. In this study, we investigated the effects of homocysteine (Hcy) on the expression of enhancer of zeste homolog 2 (EZH2), and tested our hypothesis(More)
Under complicated conditions, it is necessary for environmental monitoring to design a wireless monitoring alarm system which can replace the wired system or as a supplement. The system discussed here bases on ARM7 microprocessor named LPC1114 and transceiver module named CC2530. With ZigBee, CSM/GPRS, this system uses multiple sensors to self-organized(More)
  • Yang Yang, Liu Hao, Gu Chunguang, Li Nan
  • 2015
The newly proposed concept, the Regional Pattern for Ecological Security (RPES), provided an integrated strategy for implementing ecosystem restoration and biodiversity conservation at regional scale. Based on the concept and its theoretical basis, the designing principles and a preliminary method were put forward. With the method, the Regional Pattern for(More)