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  • Qing-Bin Lu, Xiao-Ai Zhang, Ying Wo, Hong-Mei Xu, Xiu-Jun Li, Xian-Jun Wang +9 others
  • 2012
Coxsackieviruses A10 (CV-A10) and A6 (CV-A6) have been associated with increasingly occurred sporadic hand-foot-mouth disease (HFMD) cases and outbreak events globally. However, our understanding of epidemiological and genetic characteristics of these new agents remains far from complete. This study was to explore the circulation of CV-A10 and CV-A6 in HFMD(More)
This paper presents a new spectral envelope conversion method using deep neural networks (DNNs). The conventional joint density Gaussian mixture model (JDGMM) based spectral conversion methods perform stably and effectively. However, the speech generated by these methods suffer severe quality degradation due to the following two factors: 1) inadequacy of(More)
The spectral envelope is the most natural representation of speech signal. But in voice conversion, it is difficult to directly model the raw spectral envelope space, which is high dimensional and strongly cross-dimensional correlated, with conventional Gaussian distributions. Bidirectional associative memory (BAM) is a two-layer feedback neural network(More)
BACKGROUND The prognostic importance of B-type natriuretic peptide (BNP) or N-terminal pro BNP (NT-proBNP) in patients with end-stage renal disease (ESRD) remains controversial. METHODOLOGY/PRINCIPAL FINDINGS We conducted an unrestricted search from the MEDLINE and EMBASE in all languages that were published between 1966 and Augest2013. Twenty-seven(More)
It still needs to be elucidated whether co-detection of EV71 with other intestinal tract viruses plays a role in the pathogenesis of severe hand-foot-mouth disease (HFMD). A total of 680 stool specimens collected from clinically diagnosed mild and severe-HFMD patients were tested for EV71, CA16, norovirus, bocavirus and rotavirus. The results showed that(More)
OBJECTIVE To evaluate factors associated with myopic shift among primary school children. METHODS In a one-year prospective school-based study, 5052 children from ten schools were enrolled using a multi-stage random cluster approach. The baseline examination included non-cycloplegic auto-refractometry and questionnaire interview. Measurements were(More)
In this study, we applied structure-based virtual screening techniques to identify natural product or natural product-like inhibitors of iNOS. The iNOS inhibitory activity of the hit compounds was characterized using cellular assays and an in vivo zebrafish larvae model. The natural product-like compound 1 inhibited NO production in LPS-stimulated Raw264.7(More)
  • Li-Juan Liu, Bingyong He, Jennifer A. Miles, Wanhe Wang, Zhifeng Mao, Weng Ian Che +5 others
  • 2016
Inactivation of the p53 transcription factor by mutation or other mechanisms is a frequent event in tumorigenesis. One of the major endogenous negative regulators of p53 in humans is hDM2, a ubiquitin E3 ligase that binds to p53 causing proteasomal p53 degradation. In this work, a library of organometallic iridium(III) compounds were synthesized and(More)