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The esrB gene of Edwardsiella tarda, which encodes a regulator protein of the type III secretion system, was mutated by the unmarked deletion method and reintroduced by allelic exchange into the chromosome of E. tarda LSE40 by means of the suicide vector pRE112. The LSE40 esrB mutant was highly attenuated when inoculated intraperitoneally into turbot(More)
This paper introduces an intersection accident prediction model by applying BP neural network, which can well structure the corresponding function of intersection traffic conditions and accident form, and the paper trains and predicts the model with 197 intersection data, the test results show that the prediction accuracy can reach up to 89 percent. The(More)
This paper presents a new method to design optimal disturbance rejection PID controllers for time delay system, based on genetic algorithms. The powerful capability of GA in locating the optimal solution to a given problem is exploited by optimizing the parameters of the PID controller. Each set of controller parameters is directly evaluated by simulating(More)
An effective malaria vaccine is a public health priority. Proteins expressed during the blood-stage of the parasite life cycle have been proposed as good vaccine candidates. No such blood-stage vaccine, however, is available against Plasmodium falciparum, the deadliest Plasmodium species. We show here that P. falciparum serine repeat antigen 5 (SERA5) is a(More)
Antibodies are considered as 'magic bullets' because of their high specificity. It is believed that antibodies are too large to routinely enter the cytosol, thus antibody therapeutic approach has been limited to extracellular or secreted proteins expressed by cancer cells. However, many oncogenic proteins are localized within the cell. To explore the(More)
Sporadic Alzheimer's (AD) and Parkinson's disease (PD) are late-onset neurodegenerative diseases with tremendous impact on lives of affected individuals. There is a great probability of developing concurrent Parkinsonism in AD and vice-versa than would be predicted by independent prevalence of each disease. We hypothesize that in sporadic AD as well as PD a(More)
OBJECTIVES To examine the association between fibroblast growth factor receptor-4 (FGFR-4) genetic polymorphisms (Gly-388Arg) and prostate cancer susceptibility. METHODS A comprehensive search was conducted to identify all case-control studies of FGFR-4 polymorphisms and prostate cancer risk. Statistical analysis was performed with the software program(More)
BACKGROUND The concomitant prevalence of obstructive sleep apnea hypopnea syndrome (OSAHS) and pulmonary embolism (PE) is strikingly high, and therefore we studied the patients with PE to determine whether those who had OSHAS required greater warfarin doses to achieve a therapeutic international normalized ratio (INR). METHODS By using computer(More)
Visual attention plays a critical role in game playing. A better understanding of the allocation of visual attention can benefit the design of game scenarios. In this paper we propose to design games in different difficulty levels based on the estimation of attention. We use eye movement information in an analysis of attention. Eye fixation and pursuit(More)