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Adjuvant chemotherapy has been shown to improve survival rates of postoperative patients with non-small cell lung cancer (NSCLC). Biomarkers could help select an appropriate chemotherapy for NSCLC patients or predict the efficacy of chemotherapy. The objective of this study was to explore the possible prognostic and predictive role of topoisomerase II alpha(More)
Minimally modified low density lipoprotein (mmLDL) is a well-known risk factor for coronary artery disease. Upregulation of vascular endothelin type B (ET(B)) receptors on the vascular smooth muscle cells is predicted to be the molecular mechanism that leads to cardiovascular pathogenesis. The objective of the present study was to examine the hypothesis(More)
Micro simulation programs are often used to assess the quality of traffic conditions. They are especially suited to evaluate possible control scenarios in advance, so that the scenarios can be selected and optimized before implementation. Of course, the simulation programs should be valid for the traffic situation that has to be modeled with respect to the(More)
The value of local ecological knowledge (LEK) to conservation is increasingly recognised, but LEK is being rapidly lost as indigenous livelihoods change. Biodiversity loss is also a driver of the loss of LEK, but quantitative study is lacking. In our study landscape in SW China, a large proportion of species have been extirpated. Hence, we were interested(More)
Sporadic Alzheimer's (AD) and Parkinson's disease (PD) are late-onset neurodegenerative diseases with tremendous impact on lives of affected individuals. There is a great probability of developing concurrent Parkinsonism in AD and vice-versa than would be predicted by independent prevalence of each disease. We hypothesize that in sporadic AD as well as PD a(More)
The esrB gene of Edwardsiella tarda, which encodes a regulator protein of the type III secretion system, was mutated by the unmarked deletion method and reintroduced by allelic exchange into the chromosome of E. tarda LSE40 by means of the suicide vector pRE112. The LSE40 esrB mutant was highly attenuated when inoculated intraperitoneally into turbot(More)
BACKGROUND The concomitant prevalence of obstructive sleep apnea hypopnea syndrome (OSAHS) and pulmonary embolism (PE) is strikingly high, and therefore we studied the patients with PE to determine whether those who had OSHAS required greater warfarin doses to achieve a therapeutic international normalized ratio (INR). METHODS By using computer(More)
The problem of time delay speed feedback in the control loop is considered here. Its effects on the linear stability and dynamic behavior of the maglev system are investigated. It is found that a Hopf bifurcation can take place when the time delay exceeds certain values. The stability condition of the maglev system with the time delay is acquired. The(More)
In the field of data mining, it is often encountered to perform cluster analysis on large data sets with mixed numeric and categorical values. However, most existing clustering algorithms are only efficient for the numeric data rather than the mixed data set. For this purpose, this paper presents a novel clustering algorithm for these mixed data sets by(More)