Li Hwei Yang

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A synthetic heparin pentasaccharide with sole anti-Xa actions has been evaluated for its antithrombotic efficacy in a dog model of hemodialysis. Various dosages of pentasaccharide, 400-800 nmol/kg, were compared with a single bolus dose of unfractionated heparin (250 U/kg). The primary endpoint in these studies was the duration of dialysis time. In(More)
BACKGROUND Antithrombin agent, argatroban, is currently undergoing several clinical trials for cardiovascular indications. Because of its solubility, this drug is usually administered via an intravenous bolus followed by infusion. The purpose of this study was to determine the pharmacokinetics of argatroban after intravenous bolus injection in primates. (More)
Varying dosages of pentasaccharide (400-800 nmol/kg) were compared to a 250-U/kg single bolus dosage of unfractionated heparin (UFH) in a dog model of hemodialysis. Several laboratory assays were used to monitor the effects of pentasaccharide and UFH. The pentasaccharide did not produce any anticoagulant effects as measured by the activated partial(More)
99mTc-labeled dextran has been suggested as a lymphoscintigraphic agent. However, quality-control results from previous studies have been controversial. In this study, the optimal concentration of stannous ion and pH value were determined to obtain maximal labeling. Paper and thin-layer chromatography showed total labeling efficiency as high as 98.4%.(More)
Clopidogrel is an antiplatelet drug which has undergone extensive clinical trials in the management of stroke and other arterial disorders related to platelet activation. This agent is believed to produce the inhibition of ADP mediated direct and indirect actions leading to platelet adhesion/aggregation and other activation processes. Several other observed(More)
SR46349 is a novel, selective 5-HT2 receptor antagonist with the chemical structure {trans, 4-[(3Z)3-(2-dimethylaminoethyl) oxyimino-3(2-flurophenyl) propen-1-yl]phenol hemifumarate}. This agent has been found to exhibit antithrombotic actions in animal models of thrombosis. In order to investigate the effects of this agent on agonist induced vascular(More)
Defibrotide is a polydeoxyribonucleotide derived agent with a weight average of 15 to 18 kDa. By virtue of its chemical nature, this polyelectrolyte agent exerts multiple pharmacologic actions at various plasmatic and cellular sites. In recent studies, this agent has been demonstrated to exhibit cardioprotective and vasomodulatory actions. To test the(More)
Clopidogrel is a thienopyridine derived antiplatelet drug that has currently undergone extensive clinical trials in the management of various arterial disorders related to platelet activation. While the proposed mechanism of its pharmacologic action is believed to be the inhibition of ADP mediated direct and indirect actions on platelet adhesion/aggregation(More)
Low molecular weight heparins (LMWHs) are a diverse group of depolymerized heparin preparations with molecular weights ranging from 1800 to 12,000 Da. Due to manufacturing differences, there are marked structural variations between LMWHs that exhibit distinct pharmacologic and biochemical profiles. Pharmacokinetic studies generally use indirect(More)
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