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Echinoid is a component of adherens junctions that cooperates with DE-Cadherin to mediate cell adhesion.
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Cell adhesion molecule Echinoid associates with unconventional myosin VI/Jaguar motor to regulate cell morphology during dorsal closure in Drosophila.
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Thrombin induces expression of twist and cell motility via the hypoxia‐inducible factor‐1α translational pathway in colorectal cancer cells
TLDR
The findings show that thrombin upregulates Twist via HIF‐1α to make tumor cells malignant and also establish a link between the coagulation disorder and cancer metastasis.
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Supercritical carbon dioxide extraction of aromatic turmerone from Curcuma longa Linn. induces apoptosis through reactive oxygen species-triggered intrinsic and extrinsic pathways in human…
TLDR
Results suggest that ar-turmerone-induced apoptosis in HepG2 cells is through ROS-mediated activation of ERK and JNK kinases and triggers both intrinsic and extrinsic caspase activation, leading to apoptosis.
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Supercritical carbon dioxide extraction of turmeric oil from Curcuma longa Linn and purification of turmerones
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Neural stem cells promote nerve regeneration through IL12-induced Schwann cell differentiation
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Aciculatin Induces p53-Dependent Apoptosis via MDM2 Depletion in Human Cancer Cells In Vitro and In Vivo
TLDR
Results indicate that aciculatin treatment induces cell cycle arrest and apoptosis via inhibition of MDM2 expression, thereby inducing p53 accumulation without significant DNA damage and genome toxicity.
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Differential adhesion and actomyosin cable collaborate to drive Echinoid-mediated cell sorting
TLDR
It is proposed that Ed-mediated cell sorting is driven both by differential Ed adhesion that induces cell segregation with a jagged border and by actomyosin cable assembly at the interface that smoothens this border.
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Activated PAR-2 regulates pancreatic cancer progression through ILK/HIF-α-induced TGF-α expression and MEK/VEGF-A-mediated angiogenesis.
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Moscatilin inhibits migration and metastasis of human breast cancer MDA-MB-231 cells through inhibition of Akt and Twist signaling pathway
TLDR
In an MDA-MB-231 metastatic animal model, moscatilin significantly suppressed breast cancer metastasis to the lungs and reduced the number of metastatic lung nodules and lung weight without causing any toxicity.
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