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The development of the devastating neurodegenerative condition, Alzheimer's disease, is strongly associated with amyloid-beta (Abeta) deposition, neuronal apoptosis, and cell loss. Here, we provide evidence that implicates these same mechanisms in the retinal disease glaucoma, a major cause of irreversible blindness worldwide, previously associated simply(More)
Mammalian noncoding microRNAs (miRNAs) are suggested to be involved in immune system function. We found that miR-155 expression was highly correlated with disease severity in patients with multiple sclerosis and mice with experimental autoimmune encephalomyelitis (EAE). Knockdown of miR-155 resulted in low Th1 and Th17 cells and mild EAE, and its(More)
A Rota-Baxter operator of weight λ is an abstraction of both the integral operator (when λ = 0) and the summation operator (when λ = 1). We similarly define a differential operator of weight λ that includes both the differential operator (when λ = 0) and the difference operator (when λ = 1). We further consider an algebraic structure with both a(More)
Because of the crucial role coarse roots (>2 mm diameter) play in plant functions and terrestrial ecosystems, detecting and quantifying the size, architecture, and biomass of coarse roots are important. Traditional excavation methods are labor intensive and destructive, with limited quantification and repeatability of measurements over time. As a(More)
The GPR indices used for predicting root biomass are measures of root radar reflectance. However, root radar reflectance is highly correlated with root water content. The objectives of this study are to assess the impact of root water content on GPR-based root biomass estimation and to develop more reliable approaches to quantify root biomass using GPR.(More)
Rates of acquisition and clearance of cervical human papillomavirus (HPV) during a 3-year period in women 51 years of age were compared with rates in younger women to provide data on cervical screening for women >50 years of age. Paired, cytologically negative, archived cervical smears taken 3 years apart from 710 women in Nottingham, United Kingdom, were(More)
Sulforaphane (SFN) is an organosulfur compound present in vegetables and has potent anti-oxidant and anti-inflammatory activities. This study was aimed at investigating the effect of treatment with SFN on inflammation and oxidative stress, and the potential mechanisms underlying the action of SFN in experimental autoimmune encephalomyelitis (EAE) in C57BL/6(More)
PURPOSE To investigate the effect of IOP on retinal ganglion cell (RGC) apoptosis and correlate the effects with IOP-induced changes in extracellular matrix (ECM) in the retina and optic nerve head (ONH) in glaucomatous rat eyes. METHODS Thirty-seven Dark Agouti rats had elevated IOP induced in the left eye by hypertonic saline episcleral vein injections.(More)
A platinum-based two-drug regimen is currently the standard of care for patients with advanced non-small-cell lung cancer (NSCLC). However, chemotherapy-induced side effects still remain a significant clinical problem. Astragalus polysaccharide (APS) is a polysaccharide isolated from the radix of astragalus membranaceus, a commonly used herbal compound in(More)