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Prooxidants, CCl (1 mg/kg) and alloxan (160 mg/kg), increase the intensity of spontaneous chemiluminescence of the rat blood serum by 50-100% after 72 and 48 h, respectively. The injection of antioxidant, tocopheryl acetate (100 mg/kg) 15 min after the prooxidant treatment normalizes the chemiluminescence of blood serum.